The continuum damage mechanics (CDM) approach is widely used to model damage in polymer matrix composite materials which are represented using the homogenized properties of the fiber and matrix constituents. CDM simplifies the problem of accounting for a large number of defects in a material by considering the homogenized effect of the defects as a change in constitutive properties of the material. However, recent investigations of textile composites have shown that CDM inaccurately predicts the direction of damage zone growth for some composite architectures which fail under shear load, tending to predict failure transverse to the fibers. This behavior is fundamentally attributable to the fact that shear failure in textiles results in large (tow-scale) matrix cracks, while CDM is intended to model distributed micro-cracks. It is shown that when CDM is used to model shear failure in anisotropic continua, material anisotropy tends to cause CDM to predict failure contrary to what is expected for these structures. An approach is presented that may allow CDM to better predict damage growth for shear failure in composites by encouraging the creation of an intial damage zone with sufficient directional bias to overcome the effect of material anisotropy.

The continuum damage mechanics (CDM) approach is widely used to model damage in polymer matrix composite materials which are represented using the homogenized properties of the fiber and matrix constituents. CDM simplifies the problem of accounting for a large number of defects in a material by considering the homogenized effect of the defects as a change in constitutive properties of the material. However, recent investigations of textile composites have shown that CDM inaccurately predicts the direction of damage zone growth for some composite architectures which fail under shear load, tending to predict failure transverse to the fibers. This behavior is fundamentally attributable to the fact that shear failure in textiles results in large (tow-scale) matrix cracks, while CDM is intended to model distributed micro-cracks. It is shown that when CDM is used to model shear failure in anisotropic continua, material anisotropy tends to cause CDM to predict failure contrary to what is expected for these structures. An approach is presented that may allow CDM to better predict damage growth for shear failure in composites by encouraging the creation of an intial damage zone with sufficient directional bias to overcome the effect of material anisotropy.

Typescript. Includes vita and abstract. Includes bibliographical references (leaves -). Also available online in Scholars' Bank; and in ProQuest, free to University of Oregon users.

Thesis (Ph. D.)--Ohio State University, 2003. / Title from first page of PDF file. Document formatted into pages; contains x, 78 p. : ill. Includes abstract and vita. Advisors: Lyle D. Schmidt and John D. Corrigan, Dept. of Psychology. Includes bibliographical references (p. 74-78).

Thesis (M.Psych(ClinNeurof&ClinPsych)) - University of Queensland, 2001. / Includes bibliography.

Thesis (Ph. D.)--York University, 1999. Graduate Programme in Psychology. / Typescript. Includes bibliographical references (leaves 60-65). Also available on the Internet. MODE OF ACCESS via web browser by entering the following URL: http://wwwlib.umi.com/cr/yorku/fullcit?pNQ43434.

Thesis (MAppSc in Physiotherapy) -- University of South Australia, 1998

Thesis (MAppSc in Physiotherapy) -- University of South Australia, 1998

Wild pigs are known to be an agricultural pest, but few studies have been done to quantify wild pig damage to corn and the landscape characteristics that are conducive to this damage. In the Mississippi Alluvial Valley, only 15 of the 125 sampled corn fields were damaged (12%). Using yield estimates, input costs and hectares of crop lost, this study concluded that wild pigs cause US$1,753 of damage per hectare. The proportion of corn that was planted within selected buffer scales consistently had a negative effect on whether a field would be damaged. The proportion of soybean planted within the buffer, and the proportion of disturbance had negative impacts on whether a field would be damaged. At multiple buffer scales, the proportion of shrub/scrub, adjacent crops and forest had negative effects on the amount of damage seen in a damaged field.

The role of the tumor suppressors p53 and p16 genes in the cellular response to Ultraviolet light. SUMMARY Proliferating cells respond to DNA damage by concomitantly arresting cellular growth at checkpointsa nd activating DNA repair processesC. ell cycle arrestsa re mediated,i n part, by the inhibition of cyclin-dependent kinases (CDKs), whose function is required for cell cycle progression. p53, p21WAF' and p16`NK4aa re the products of tumor suppressor genes that play important roles during the cellular response to genotoxic stresses. p53 and p16 coding genes have been found mutated or transcriptionally silenced in different cancer types both sporadic and familial. Indeed, p16 has been found to be linked to familial melanoma, whose etiology is related to sun-light induced DNA damage. It is hence important to ascertain whether p53 and p16 are involved in the cellular response to UV damage. In this report I present evidence that p53 is not involved in UV-induced cellular growth arrest in late G1 phase. This has been demonstrated in HeLa cells synchronized at the G1/S border by aphidicolin, followed by UV exposure. Interestingly, the length of this p53-independent G1 arrest has been shown to be UV dose-dependent. Similar results were also obtained with other p53-deficient cell lines, including the human promyelocytic leukemia HL-60 and mouse p53 knock-out cells. As expected, all of these cell lines were defective in v-ray-induced cell growth arrest at late G1Using different assays I also show here that p16-compromised U20S osteosarcoma cells are deficient in the removal of UV damage, as compared to their isogenic derivatives EH1 and EH2 counterparts that express p16. This deficiency is associated with a high level of UV-induced apoptosis, which is significantly reduced in the p16-expressing EH I, EH2 and p16+/+ mouse embryonic fibroblast (MEF) cells, indicating that p16 protects cells from undergoing apoptosis in response to UV light. Importantly, this reduction in UV-mediated apoptosis was associated with down-regulation of the pro-apoptotic Bax protein, with no effect on Bcl-2 expression, suggesting that this anti-apoptotic role of p16 is mediated via the intrinsic p53-dependent mitochondrial pathway. On the other hand, p16 sensitized cells to cisplatin-mediated apoptosis through Bcl-2 decline. Furthermore, I show that p16 is involved in UV-related G1 checkpoint and controls the expression and UV-dependent activation of another CDK inhibitor, p21wAFI. Importantly, this relationship between p16 and p21 exists also in MEFs, suggesting that it is not cell type- or species-dependent. These results indicate that, in addition to its role in cell cycle control and senescence, p16 also plays an important role in the cellular response to UV damage, possibly by inhibiting apoptosis and facilitating cell cycle arrest and photolesion removal. The data presented here provide further insights into the role of p53 and p16, as tumor suppressors, in carcinogenesis and have potential implications for future therapy strategies