Corn (Zea mays L.) defoliation experiments have been conducted for more than 120 years. However, there is limited data on the effect of row width on defoliation in modern hybrids. A two-year experiment was conducted in Lexington, Kentucky with two hybrids (113 relative maturity (RM) and 120 RM), two row widths (38 and 76 cm) and a combination of defoliation timings and severities: 0% defoliation (control), V7-100%, V14-50%, V14-100%, R2-50% and R2-100%. No yield difference among hybrids was observed in 2012. Yields were 26% greater in 38-cm rows than 76-cm rows in 2012. For 2013, corn yield for 38-cm was 10% greater, but hybrid, row width and defoliation interacted. Lowest yields were caused by V14-100% followed by R2-100%. Defoliations of V14-50% and R2-50% reduced yields in some cases. Complete defoliations at V7 did not reduce yields in most comparisons. Light interception below 80% during the critical period was enough to attain maximum yields in defoliated plants. Kernel number and kernel weight were most reduced by V14-100% and R2-100% defoliations, respectively. There is a potential for narrow rows to reduce grain yield losses after a defoliation event, when compared with wide rows.