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A study of sterically stabilized vesiclesJamshaid, Mohammad January 1989 (has links)
No description available.
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The freeze drying of liposomes for pulmonary administrationSammour, O. A. A. January 1988 (has links)
No description available.
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203 |
Transdermal delivery of anti-inflammatory agentsChan, Sui Yung January 1991 (has links)
No description available.
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204 |
Formulation and evaluation of novel amphotericin B oil/water triglyceride emulsionsLance, Martin Richard January 1996 (has links)
No description available.
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205 |
Radiolabelling of pharmaceutical dosage forms by neutron activation of Samarium-152Awang, Mohamed Bin January 1995 (has links)
No description available.
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Oil-in-water emulsions for intravenous drug deliveryWest, P. E. January 1988 (has links)
No description available.
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Reconstituted Sendal virus envelopes as intra-articular drug vectorsEarl, R. T. January 1987 (has links)
No description available.
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Strategies for microsphere-mediated cellular deliveryCardenas-Maestre, Juan Manuel January 2011 (has links)
Amino-functionalised polystyrene microspheres are promising candidates as delivery systems due to their unique features, tunable surface functionalities, and controllable release of the cargo. Herein several strategies for the conjugation of biologically relevant cargoes to these microspheres and their biological evaluation are described. Firstly, dispersion and suspension polymerisation methods were applied for the synthesis of these devices. Subsequently, these polymeric particles were employed in multistep solid phase synthesis to conjugate a broad range of cargoes. The capability of the resulting constructs to cross the cell membrane and deliver the desired cargo was evaluated by flow cytometry and confocal microscopy. Additionally, the effect of these particles on cell viability was determined. Moreover a chemical strategy for dual fuctionalisation allowed the production of microspheres capable of carrying two cargos simultaneously (e.g. a biologically relevant cargo and a tracking fluorophore). Several strategies were used to transport biomolecules such as peptides and oligonucleotides inside cells. Cell-impermeable peptides with neuroprotective activity were conjugated to microspheres to facilitate their internalisation and they were efficiently delivered into neuroblastom cells (SH-SY5Y) without affecting their therapeutic activity. In addition, several microsphere-mediated oligonucleotide delivery strategies were investigated. As a first approach, siRNA was successfully attached to microspheres via thiol linkage or via electrostatic interaction (by formation of polycationated microspheres-siRNA microplexes). Using both strategies EGFP expression was efficiently down-regulated in cervical cancer cells permanently expressing EGFP (HeLa-EGFP) following beadfection. Additionally embryonic stem (ES) cells were beadfected with siRNA linked to microspheres by amide formation and essential transcription factors implicated in cell renewal and differentiation were successfully silenced, exceeding the silencing capabilities of commercially available lipofection products. Furthermore, a novel approach for the intracellular delivery of plasmid DNA was designed. Following an easy protocol for the linearisation and functionalisation of the plasmid DNA, this was covalently coupled to beads and cells were homogeneously ‘beadfected’. Finally, the coupling of fluorogenic substrates for caspase-3 to microspheres allowed the in situ monitoring and quantification of apoptotic process within cells. In conclusion, these small particles are excellent devices for the efficient intracellular delivery of a broad range of cargoes.
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Developing a national cadre of effective leadership for sustainable and quality service delivery17 September 2013 (has links)
D.Phil. (Leadership Performance and Change) / Please refer to full text to view abstract
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210 |
Reactions of mothers to labor and delivery: effects of preparation and supportHeckerman, Luanne Davis, Morry, Mary R., LCDR January 1966 (has links)
Thesis (M.S.)--Boston University / PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you. / 2031-01-01
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