Thesis (M.S.)--University of Michigan, 1971.

Thesis (M.S.)--University of Michigan, 1983.

Thesis (M.S.)--University of Michigan, 1971.

nÃo hà / A periodontite agressiva representa um tipo de doenÃa periodontal inflamatÃria que, embora rara, geralmente acomete indivÃduos em idade precoce e à caracterizada pela destruiÃÃo rÃpida e debilitante do periodonto de suporte. A patogÃnese desta doenÃa vincula-se a um fator etiolÃgico primÃrio, o biofilme dental e tambÃm à resposta inflamatÃria do hospedeiro susceptÃvel à agressÃo bacteriana. O objetivo deste estudo foi avaliar o efeito do tratamento a curto prazo com etoricoxib como adjuvante à terapia de raspagem e alisamento radicular (RAR) sobre os nÃveis de PGE2 e sobre os parÃmetros clÃnicos e radiogrÃficos em pacientes portadores de periodontite agressiva. Os pacientes foram randomicamente alocados para TESTE e CONTROLE (n=10 em cada grupo) e submetidos ao tratamento com etoricoxib (120 mg/dia) ou placebo durante 7 dias. Profundidade de sondagem (PS), nÃvel de inserÃÃo clÃnica (NIC), recessÃo gengival (RG), Ãndice de placa visÃvel (IP), sangramento à sondagem (SS), mensuraÃÃo da distÃncia linear (DL) e anÃlise dos nÃveis de cinza (NC) foram registrados antes e um mÃs apÃs a instituiÃÃo das terapias. A anÃlise visual por vÃdeo e por negatoscÃpio bem como a anÃlise por subtraÃÃo radiogrÃfica digital foram feitas no inÃcio e ao final do perÃodo experimental. A dosagem de PGE2 no fluido crevicular gengival (FCG) foi avaliada por radioimunoensaio no inÃcio, com 7 dias apÃs o inÃcio dos tratamentos e 30 dias apÃs a finalizaÃÃo dos mesmos. Ao final do perÃodo experimental, nÃo foram observadas diferenÃas estatisticamente significantes entre os grupos em relaÃÃo aos parÃmetros clÃnicos, embora ambos os grupos tenham apresentado melhora significativa em todas as variÃveis avaliadas. Houve um decrÃscimo no NIC de 5,54Â0,47 mm para 3,59Â0,53 mm no grupo TESTE e de 5,92Â1,10 para 3,69Â0,80 mm no grupo CONTROLE. Uma significativa reduÃÃo nos nÃveis de PGE2 foi observada apÃs 7 dias de tratamento. A mensuraÃÃo da DL evidenciou diferenÃa entre os grupos. Em conclusÃo, etoricoxib nÃo foi capaz de promover benefÃcio adicional nos parÃmetros clÃnicos, contudo, promoveu reduÃÃo inicial nos nÃveis de PGE2 e discreta melhora na condiÃÃo Ãssea. / Aggressive periodontitis is an inflammatory type of periodontal disease which, although rare, generally affects individuals at an early age and is characterized by the rapid and debilitating destruction of the support periodontium. The pathogenesis of this pathology is related to primary etiologic factor, dental biofilm, associated to the immunoinflammatory response of susceptible host to this aggression. The purpose of this study was to assess the effect of short duration treatment with etoricoxib as adjuvant therapy to scaling and root planing (SRP) on prostaglandin E2 (PGE2) levels and the clinical and radiographic parameters in aggressive periodontitis. Patients were randomly allocated to TEST or CONTROL (N=10 in each group) and submitted to SRP and treatment with 120 mg/day of etoricoxib or placebo during 7 days. Probing depth (PD), clinical attachment level (CAL), gingival recession (GR), visible plaque index (VPI), bleeding on probing (BOP), measurement of the linear distance (LD) and analysis of the gray levels (GL) were recorded before and one month after the therapies. The visual analysis from video and negatoscope and digital subtraction radiographic was made in beginning and in the final experimental period (30 days). The PGE2 dosage in the gingival crevicular fluid (GCF) was measured by radioimmunoassay at the beginning, and 7 and 30 days afterwards. No significant difference was observed between the groups in the clinical parameters at the end of the experimental period, although both groups presented significant improvement in all the variables examined. There was a decrease in CAL from 5.54Â0.47 mm to 3.59Â0.53 mm in the TEST group and from 5.92Â1.10 to 3.69Â0.80 mm in the CONTROL group. A significant reduction in PGE2 was found after 7 days of treatment. The LD measurement was shown to differ between the groups. In conclusion, etoricoxib did not promote additional improvement in the clinical parameters, however it produced an initial reduction in the PGE2 levels in the GCF, which could be related to the discrete improvement in the bone condition.

Introduction: Dental implant abutments can be exposed to a variety of oral prophylaxis procedures. Instrumentation of restored dental implants could subject the apical collar of the implant restorative abutment to surface scratching. Scratched surfaces may pose a threat to the integrity of the soft-tissue seal around the apical portion of the abutment which eventually may compromise the alveolar support of the implant. The aim of this study was to objectively measure surface roughness on the apical collar of metal implant abutments induced by probing and scaling instruments. Materials and Methods: 14 standard transmucosal 3 in 1, 4.5 mm diameter abutments made of titanium alloy (BioHorizons, Atlanta, GA) and 4 instruments, UNC-15 metal probe, Periowise plastic probe, McCall SM 17/18 metal scaler and universal plastic scaler were used to conduct the study. 4 abutments were used for non-treated measures and 10 abutments were used for instrumentation measures. All abutments were divided into four sections. Abutments used for instrumentation were treated with one of the four indicated instruments, one instrument per each section. Surface roughness of untreated and treated surfaces was assessed using a contact profilometer. Analysis of variance (ANOVA) was used to compare surface roughness between untreated and treated surfaces. Results: ANOVA showed significant differences in surface roughness between the treated and untreated surfaces (p< 0.0001). Add hoc analysis using Tukey-Kramer HSD test showed no statistical differences between untreated measures and metal probe measures (p>0.05). On the other hand, statistical differences were noted between untreated measures with plastic probe measures (p= 0.05), plastic scaler measures (p=0.05) and metal scaler measures (p=0.05). The metal scaler measures were higher than plastic probe measures (p=0.05), and plastic scaler measures (p=0.05). Conclusions: Probing around implant abutments with a metal probe seems to have no relevant effect on abutment surfaces. In contrast, instrumentation with scalers (both metal and plastic) and plastic probe may cause adverse surface changes. It is not known if these changes have clinical relevance. / Oral Biology

Thesis (M.S.)--University of Michigan, 1966.

Thesis (M.S.)--University of Michigan, 1983.

Thesis (M.S.)--University of Michigan, 1962.

Thesis (M.S.)--University of Michigan, 1961.

Thesis (M.S.)--University of Michigan, 1966.