To determine whether or not systematic desensitization treatment would produce a significant reduction in negative affect evoked by racial discrimination, 60 Mexican-American college students who scored above average on the Terrell Racial Discrimination Index were selected and assigned randomly to one of three treatment conditions: systematic desensitization (DS), therapist contact (TC), and no-treatment control (NTC). Before undergoing treatment, subjects completed the Background Information Questionnaire (BIQ), and three measures of negative affect: the Multiple Affect Adjective Check List (MAACL); the Profile of Mood States (POMS); and the Treatment Rating Scales (TRS). After concluding treatment, subjects completed the three measures of negative affect only. Results were nonsignificant with respect to two of the affect measures—the POMS and the MAACL. However, significant differentia1 treatment effects were observed for the TRS measure. Relative to the TC and NTC conditions, subjects in the DS condition evidenced significantly less anger, depression, and anxiety. No other group differences attained the level of statistical significance (p < .05). Several explanations are offered for the negative findings of the MAACL and POMS. These explanations include the possibility that the measures themselves are insensitive to treatment effects. Nevertheless, due to the significant findings of the TRS, it is concluded that systematic desensitization proves effective in alleviating the negative emotional responses of Mexican Americans to racial discrimination. The implications of these findings are discussed.