The impact of fashion industry on the environment is evident and manifest in its sheer numbers. The industry accounts for 17–20 percent of global industrial water pollution (Kant 2012). It also contributes between four and ten percent of global carbon emissions (Sadowski et al. 2021). The fashion industry can therefore be labeled as a ‘climate killer’ whose overproduction is consuming our resources on a global scale.

工学設計とは,複数の性能要求を満たすべく,膨大な数の設計変数の最適値を求め,自らが望む設計を選択していく,設計探査と意思決定のプロセスである. 本研究では,これら２つの主要課題に対して,多様かつ優れた解を高速に得るための「設計空間探査」と高次元かつ膨大な設計候補群から主要な設計パターンを抽出し,その特徴を定量的に分析するための「設計モード解析」の技術を開発し,その有効性を示した. / In engineering design, we try to find better solutions that satisfy many design requirements. Once the designs have been found, we choose preferable one. Engineering design is the mixed procedure of design exploration and decision making. This study proposes the effective solution for each engineering process: (1) a novel optimization algorithm to rapidly derive better designs, and (2) "design mode analysis" which enables us to extract representative design patterns from the huge number of design examples. Effectiveness of the proposed method were verified in real-world problems. / 博士(工学) / Doctor of Philosophy in Engineering / 同志社大学 / Doshisha University

Over the course of the last decades, the continuous exposure of bacteria to antibiotics—at least in parts due to misprescription, misuse, and misdosing—has led to the widespread development of antimicrobial resistances. This development poses a threat to the available medication in losing their effectiveness in treating bacterial infections. On the drug development side, only minor advances have been made to bring forward novel therapeutics. In addition to increasing the efforts and approaches of tapping the natural sources of new antibiotics, synthetic approaches to developing novel antimicrobials are being pursued. In this study, BDTL049 was rationally designed using knowledge based on the properties of natural antibiotics. BDTL049 is a carbosilane dendritic system with bow-tie type topology, which has antimicrobial activity at concentrations comparable to clinically established natural antibiotics. In this report, we describe its mechanism of action on the Gram-positive model organism Bacillus subtilis. Exposure to BDTL049 resulted in a complex transcriptional response, which pointed toward disturbance of the cell envelope homeostasis accompanied by disruption of other central cellular processes of bacterial metabolism as the primary targets of BDTL049 treatment. By applying a combination of whole-cell biosensors, molecular staining, and voltage sensitive dyes, we demonstrate that the mode of action of BDTL049 comprises membrane depolarization concomitant with pore formation. As a result, this new molecule kills Gram-positive bacteria within minutes. Since BDTL049 attacks bacterial cells at different targets simultaneously, this might decrease the chances for the development of bacterial resistances, thereby making it a promising candidate for a future antimicrobial agent.