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Study of Mechanism in Desorption Electrospray and To Improve the Process of Droplet Electrospray IonizationLin, Yu-Xiang 26 June 2006 (has links)
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Elimination of Electrochemical Oxidation during Sample Ionization Using Liquid Sample Desorption Electrospray Ionization (DESI)Almowalad, Najah K., January 2016 (has links)
No description available.
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Desorption Electrospray Ionization Mass Spectrometry Imaging: Instrumentation, Optimization and CapabilitiesDhunna, Manan 13 March 2014 (has links) (PDF)
Desorption Electrospray Ionization Mass spectrometry Imaging (DESI-MSI) is an area of great interest and a promising tool in the field of chemical imaging. It is a powerful, label-free technique, which can determine, map and visualize different molecular compounds on a sample surface. The amount of information acquired in a single DESI-MSI experiment is enormous compared to other techniques, as it can simultaneously detect different compounds with their spatial distribution on the surface. The experiment can be used to produce two-dimensional and three-dimensional images. Chapter 2 focuses on the design and optimization of the setup for performing DESI-MS imaging on various substrates. The proposed setup was tested for its lateral spatial resolution. To provide proof-of-concept of the design, preliminary tests were performed to generate images from commercial thin layer chromatographic plates and photographic paper. Chapter 3 focuses on demonstrating the compatibility of novel microfabricated Thin Layer Chromatography plates (M-TLC plates) for detection with DESI-MSI.
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Development of Ambient Mass Spectrometry for Protein/Peptide Characterization, Solvent-Free Analysis, and Electrochemical Reaction MonitoringLiu, Pengyuan 25 August 2015 (has links)
No description available.
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Development of Thermal Desorption Electrospray Ionization Mass Spectrometry and its Applications in Food SafetyLiu, Te-Lin 28 July 2012 (has links)
Ambient ionization mass spectrometry, which has witnessed a flurry of recent developments, is a set of useful techniques for the analysis of samples under open-air conditions. It allows direct, rapid, real-time, high-throughput analysis with little or no sample pretreatment for the chemicals in solids or liquids. In this study, thermal desorption electrospray ionization mass spectrometry ( TD-ESI/MS ) involving direct insertion probe ( DIP ), thermal desorption ( TD ) and electrospray ionization ( ESI ) was used for the rapid screening of various types of samples. The source mainly consists of the sampling probe device, thermal desorption heating device, electrospray ionization device, ion source and temperature controller. A novel strategy involved in TD-ESI/MS processes where sampling, desorption, and ionization are separated as three independent events. The sampling probe is first used for the sampling of analytes and then inserted into a heat unit for thermal desorption. The desorbed analytes are finally carried into a reaction region with a stream of nitrogen gas, where charged methanol droplets were generated continuously by electrospray for post-ionization. Total analysis time is less than 10 seconds.
Traditionally, three standard methods are used for the analysis for pesticide residues, biochemical, immunoassay and instrument. And, the instrument analysis is the most widely used because it provides lots of advantages in particularly accurate quantitative approach. However, its complicated steps take a long period of time for preparation. Here, we used TD-ESI/MS to rapidly screen the pesticide residues on the surface of fruits and vegetables. The MS/MS analysis was also performed to confirm those detected compounds. The experimental results of the standard deviation for reproducibility is 13.2% (n = 10), and the detection limit is approximately 10 ppb. Furthermore, several fruits and vegetables purchased from local market were used as test samples and pesticide residues on the surface of samples can be successfully detected via TD-ESI/MS. In addition, the TD-ESI/MS technique was also applied to the analysis of illegal additives or phthalates in food. In this study, the TD-ESI/MS technique emerges lots of advantages such as direct, rapid, real-time analysis of sample surface and sample pretreatment is not necessary, and shows highly potential for rapid screening of chemicals in food safety.
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Vývoj a aplikace technik ambientní hmotnostní spektrometrie / Development and applications of ambient mass spectrometry techniquesRejšek, Jan January 2017 (has links)
(EN) Ambient mass spectrometry defines the versatile group of methods providing analysis of solid sample surfaces and liquids in an open atmospheric pressure environment, where the sample is simultaneously accessible to another treatment. Ambient mass spectrometry is a sharply developing research area in the analytical chemistry. It provides fast, direct analysis of objects without any sample pretreatment with the use of the mass spectrometer. Desorption electrospray ionization (DESI) and desorption atmospheric pressure photoionization (DAPPI) equipped with software control of the sample holder were investigated in this doctoral thesis. These methods use a spray of solvents for desorption and ionization molecules from solid substrate and they are suitable tools for mass spectrometry imaging (MSI) of low molecular organic compounds, where the chemical identity of molecules present on a surface is examined as a function of spatial distribution. This project deals with applications and instrumental development. As for the applications, the position of the defense glands on insect bodies, separation of the lipids in complex mixtures on thin-layer chromatography (TLC) plates, or steroid metabolites in woman urine during pregnancy were thus investigated. As for the instrumental development, the most...
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Mass Spectrometric Analysis of Thiol Proteins/Peptides Following Selenamide Derivatization And Electrolytic Reduction of Disulfide BondsZhang, Yun January 2012 (has links)
No description available.
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Mass Spectrometric Study of Trace Chemical Analysis, Methanol Electro-Oxidation, and Enzymatic Reaction KineticsCheng, Si January 2016 (has links)
No description available.
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Development and Applications of Liquid Sample Desorption Electrospray Ionization Mass Spectrometry (DESI-MS)Miao, Zhixin January 2012 (has links)
No description available.
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Characterization of the Desorption Electrospray Ionization Mechanism Using Microscopic Imaging of the Sample SurfaceWood, Michael Craig 04 August 2011 (has links) (PDF)
Desorption electrospray ionization (DESI) is an ambient ionization technique for mass spectrometry. This solvent based desorption ion source has wide applicability in surface analysis with minimal sample preparation. Interest in improving detection limits, broadening applications, and increasing the spatial resolution for chemical imaging has led to studies of the DESI mechanism. An inverted microscope has been used to image interactions between the DESI spray and test analytes on a glass surface. Microscopic images recorded with millisecond time resolution have provided important insights into the processes governing analyte transport and desorption. These insights are the basis of a rivulet-based model for desorption that differs significantly from the widely-accepted momentum transfer model.
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