Tese de mestrado integrado. Engenharia Civil. Faculdade de Engenharia. Universidade do Porto. 2011

Thesis (Ph. D.)--University of California, San Diego, 2002. / Vita. Includes bibliographical references (leaves 127-138).

This thesis explores autobiographical practices and their relationship to autofiction, by focusing on practices of identity construction and artistic performance, as well as identity construction through performance. Emphasis is given to the ways gender and sexuality enter into, and shape, these practices by examining, in particular, the way they are expressed in Diana Thorneycroft's photographic performances. Chapter 1 discusses the history and key debates in autobiography theory, the ways gender has been introduced into the analysis of autobiography, and non-literary forms of autobiography. Chapter 1 also briefly discusses the (Western) history of art by women. Chapter 2 examines Thorneycroft's oeuvre and selected responses to it. Chapter 3 presents an analysis of autofictional practices through an examination of Thorneycroft's photographic self-portraits, thereby questioning the distinctions between autobiography and autofiction and suggesting that there is considerable overlap in their definition. The Conclusion briefly discusses agency in relation to autofictional (self-making) practices.

Techn. Universiẗat, Diss., 2006--Darmstadt.

Thesis (M.A.)--Brigham Young University. Dept. of English, 2005. / Includes bibliographical references (p. 65-69).

Following some incidents in high-rise buildings, such as Ronan Point London 1968, in which collapse of a limited number of structural elements progressed to a failure disproportionate to the initial cause, consideration of robustness was introduced in British Standard. The main method of preventing progressive collapse for providing robustness to steel framed buildings with precast concrete floor slabs focuses on the allowable tying forces that the reinforcement in between the slabs and in hollowcores should carry. However there are uncertainties about the basis of the practical rules associated with this method. This thesis presents the results of numerical and analytical studies of tie connection behaviour between precast concrete floor slabs (PCFS). It is shown that under current design regulations the tie connection is not able to resist the accidental load limit applied on the damaged floor slabs. By establishing the capability of a finite element model to depict and predict the behaviour of concrete members in situations such as arching and catenary action against several experimental tests, an extensive set of parametric studies was conducted in order to identify the effective parameters in enhancing the resistance of the tie connection between PCFSs. These parameters include: tie bar diameter, position, length, yield stress and ultimate strain; the slab’s height, length; and the compressive strength of the grouting concrete in between the slabs that encases the tie bar. Recommendations are made based on the findings of this parametric study in order to increase the resistance of the tie connection. Based on the identified effective parameters in the parametric study a predictive analytical relationship is derived which is capable of determining the maximum vertical displacement and load that the tie connection is able to undergo. This relationship can be used to enable the connection to capture the accidental limit load on a damaged slab. The identified parameters are examined in a three dimensional finite element model to assess their effect when columns of the structure are lost in different locations such as an edge, corner or internal column. Based on the findings of this study methods for improving the connections performance are presented. Also the effect of alternative transverse tying method is evaluated and it is concluded that although this kind of tie increases the load carrying capacity of the connection, its effect on the catenary action is not significant.

Millions of people worldwide die of cancer every year. In the last decade, im- munotherapy offered new treatment options achieving long-lasting remissions in a number of patients. Several new immunotherapy-based drugs have been ap- proved by Food and Drug Administration. However, majority of patients either do not respond or soon relapse. Combination of therapies as well as exploring new immune checkpoints seems promising. This thesis focuses on the new immunotherapeutic target CD73. CD73 is membrane ectonucleotidase, widely expressed on the regulatory leukocytes and on cancer cells. The enzymatically active CD73 contributes to the tumour mi- croenvironment by production of immunosuppressive adenosine. This novel im- mune checkpoint is being intensively studied. This thesis aims on development of new approaches for targeting and inhibition of CD73. Soluble recombinant CD73 (rhCD73) was prepared in mammalian expression system and transfectants stably expressing membrane-bound CD73 were prepared as well. Inhibitors necessary for both of my goals have been designed based on published inhibitor of CD73. Development and evaluation of novel antibody mimetic for CD73 characteri- sation was done. The so-called iBody, HPMA polymer conjugate decorated with CD73 inhibitor for targeting, fluorophore for...

Glutamate carboxypeptidase II (GCPII) usually called prostate specific membrane antigen (PSMA) is membrane bound metallopeptidase expressed mainly in prostate carcinoma (PCa). Agents targeting GCPII suitable for both imaging and treatment of PCa are in development and they show promising results in advanced clinical trials. Some studies showed that GCPII may serve also as PCa blood serum marker, but this has not been validated due to the lack of methods suitable for accurate detection of GCPII in human blood. Moreover, GCPII is also expressed in brain, where it cleaves inhibitory N-acetyl-α-L- aspartyl-L-glutamate (NAAG) to release excitatory L-glutamate and GCPII inhibition has been shown to be neuroprotective in animal models of several neuropathies. Tight binding inhibitors of GCPII have been identified by rational design, but all have poor bioavailability and thus cannot be used in clinics. Identifying new scaffolds by 'brute force' screening methods is thus essential; however, no such method for GCPII has been developed so far. Glutamate carboxypeptidase III (GCPIII) is also expressed in brain and cleaves NAAG. It is thus an important protein for understanding of GCPII function as well as GCPII targeting in medicine. Here, we focused on development of novel methods for quantification of both...

Millions of people worldwide die of cancer every year. In the last decade, im- munotherapy offered new treatment options achieving long-lasting remissions in a number of patients. Several new immunotherapy-based drugs have been ap- proved by Food and Drug Administration. However, majority of patients either do not respond or soon relapse. Combination of therapies as well as exploring new immune checkpoints seems promising. This thesis focuses on the new immunotherapeutic target CD73. CD73 is membrane ectonucleotidase, widely expressed on the regulatory leukocytes and on cancer cells. The enzymatically active CD73 contributes to the tumour mi- croenvironment by production of immunosuppressive adenosine. This novel im- mune checkpoint is being intensively studied. This thesis aims on development of new approaches for targeting and inhibition of CD73. Soluble recombinant CD73 (rhCD73) was prepared in mammalian expression system and transfectants stably expressing membrane-bound CD73 were prepared as well. Inhibitors necessary for both of my goals have been designed based on published inhibitor of CD73. Development and evaluation of novel antibody mimetic for CD73 characteri- sation was done. The so-called iBody, HPMA polymer conjugate decorated with CD73 inhibitor for targeting, fluorophore for...

British speculative fiction writer, Diana Wynne Jones, has published over forty books for middle school to adult readers, and her work continues to receive many awards for its creativity and high quality. Jones is a prolific and talented writer who has contributed to and influenced speculative fiction. She uses magical contexts to comment on social situations in what she sees as an essentially non-magical world. Whether she is being humorous, drawing upon myths and legends, or using fantasy or science fiction, Jones reflects the contemporary unpredictable adolescent mind. Jones's unusual childhood has influenced her writing, and a brief biography of Jones's life provides insight into her work—why certain themes have greater interest to her over others. Recurring themes in her books include alienation, empowerment, and identification. Through often convoluted plots, she encourages her readers to think for themselves. From her stories, readers learn to appreciate and accept the complexity and inexplicability of life. While her themes are consistent, her work varies. Some of her work is humorous, some is based on myths, some leans more towards science fiction than fantasy, and some seems more like fantasy than science fiction. Despite this diversity, Jones consistently seeks to learn from her own work by questioning basic assumptions and endeavors to contribute wisdom to her readers through her fiction. Jones uses myth and the heroic ideal to encourage readers to question their motives and recognize the empowerment that comes from self-sacrifice.