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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

Role of Selective Estrogen Receptors B Agonist on Chronic Lymphocytic Leukemia Growth in Vitro

Salam, Noor January 2014 (has links)
The estrogen receptor alpha (ERa) and estrogen receptor beta (ER~) have been demonstrated to be important for immune system regulation and studies have suggested an antiproliferative effect of ER~ in lymphoid malignancies. We have studied the expression of ERa and ER~ in peripheral blood mononuclear cells from patients with chronic lymphocytic leukemia (CLL). Expression of ERa was low, while ER~ was highly expressed in CLL cells. In order to investigate the possible inhibitory effect of ligand-activated ER~ , we treated CLL cells and Mecl cell lines with the selective ER~ agonist diarypropionitrile (DPN) in culture. Treating Mecl cell lines with DPN showed an antiproliferative effect of ER~ agonist by significantly inhibit the growth of Mec 1 cell lines. This suggests that ER~ agonist may be useful in the treatment of CLL.

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