In 2017, dicamba formulations were labeled for PRE and POST applications and utilized in soybean to control herbicide-resistant weed species. Dicamba-tolerant soybean cultivars were grown in proximity to those representing other herbicide-resistant technologies, creating the potential for problems with off-target movement. Field studies conducted in 2017 and 2018 in Stoneville, MS, characterized the soybean response to exposure to sub-lethal rates of different dicamba formulations and evaluated the performance of soybean cultivars representing different soybean maturity groups following multiple exposures to a sub-lethal rate of dicamba. Other field experiments in 2018 evaluated the performance of soybean following a single exposure to sub-lethal rates of dicamba at different growth stages (Rate and Timing Study) and characterized soybean response to multiple exposures of a sub-lethal rate of dicamba at different growth stages (Multiple Exposures Study).