The differential outcomes effect (DOE) refers to an observed increase in rates of acquisition of simple or conditional relations when the contingencies of reinforcement arrange for reinforcers to be uniquely correlated with a particular stimulus or response relative to conditions where the reinforcers are not uniquely correlated with either stimulus or response. This effect has been robustly documented in the literature with nonhuman subjects. This study asked whether the DOE would be observed with children with autism spectrum disorder (ASD) learning audio-visual conditional relations. Two participants learned two sets of 3 audio-visual conditional relations. For one set, the training conditions arranged for each of the three conditional relations to be uniquely correlated with a particular reinforcing stimulus (the DO condition). For the second set, the training conditions arranged for the same reinforcer to be used for all three audio-visual conditional relations (the NDO condition). Early results show that audio-visual conditional relations were acquired faster under the DO condition relative to the NDO outcomes condition (accuracy in DO condition was 30.8% higher on average than in NDO condition). These data suggest that differential outcomes should be more thoroughly investigated with children with diagnoses of ASD.