In nature, many social species demonstrate collective behavior ranging from coordinated motion in flocks of birds and schools of fish to collective decision making in humans. Such distinct behavioral patterns at the group level are the consequence of local interactions among the individuals. We can learn from these biological systems, which have successfully evolved to operate in noisy and fault-prone environments, and understand how these complex interactions can be applied to engineered systems where robustness remains a major challenge. This dissertation addresses a two-scale approach to study these interactions- one in larger scale, where we are interested in the information exchange in a group and how it enables the group to reach a common decision, and the other in a smaller scale, where we are focused in the presence and directionality in the information exchange in a pair of individuals. To understand the interactions at large scale, we use a graph theoretic approach to study consensus or synchronization protocols over two types of biologically-inspired interaction networks. The first network captures both collaborative and antagonistic interactions and the second considers the impact of dynamic leaders in presence of purely collaborative interactions. To study the interactions at small scale, we use an information theoretic approach to understand the directionality of information transfer in a pair of individual using a real-world data-set of animal group motion. Finally, we choose the issue of same-sex marriage in the United States to demonstrate that collective opinion formation is not only a result of negotiations among the individuals, but also reflects inherent spatial and political similarities and temporal delays. / Ph. D. / Social animals exhibit coordination often referred to as ‘collective behavior’ that results from interactions among individuals in the group. This dissertation has demonstrated how interactions can be studied using mathematical modeling, at the same time reveals that real-world interactions are even more complex. Mathematical modeling provides capabilities to introduce biologically inspired phenomena, for example, the implementation of both friendly and hostile interactions that may coexist; and the presence of leader-follower interactions, which is another determinant of collective behavior. The results may find applications in real-world networks, where hostile and leader-follower interactions are prevalent, for example international relations, online social media sites, neural networks, and biologically inspired robotic interactions. We further extend our knowledge regarding interactions by choosing real world systems, the first to understand human decision making, for example in public policies; and the second in animal group motion. Public policy adoption is generally complex and depends on a variety of factors, and no exception is same-sex marriage in the United States which has been a volatile subject for decades until nationwide legalization on June 26, 2015. We target this timely issue and explore the opinion formation of senators and state-law as they evolve over two decades to identify factors that may have affected the dynamics. We unravel geographic proximity, and state-government ideology are significant contributors to the senators opinions and the state-law adoption. Moreover, we build a state-law adoption model which captures these driving factors, and demonstrates predictive power. This study will help to understand or model other public policies that propagate via social and political change. Next we choose the system of bats to investigate navigational leadership roles as they fly in pairs from direct observation of bat swarms in flight. Pairs of bats were continuously tracked in a mountain cave in Shandong Province, China, from which three-dimensional path points are extracted and converted to one-dimensional curvature time series. The study allows us to answer the question of whether individuals fly independently of each other or interact to plan flight paths.