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The Global ETD Search service is a free service for researchers
to find electronic theses and dissertations. This service is
provided by the
Networked Digital Library of Theses and Dissertations.
Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
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A reconfigurable AGV with omni-directional sensingKotze, B., Jordaan, G.D., Vermaak, H. January 2010 (has links)
Published Article / Automatic guided vehicles are being used increasingly in a manufacturing environment. Developing a platform that could be easily reconfigured is perhaps a desirable option for a user with low capacity outputs. The research described in this article concentrates on such a vehicle and the development of the actuators and sensors for navigation and proper functionality.
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Protein kinase A regulates the Ras, Rap1 and TORC2 pathways in response to the chemoattractant cAMP in DictyosteliumScavello, Margarethakay, Petlick, Alexandra R., Ramesh, Ramya, Thompson, Valery F., Lotfi, Pouya, Charest, Pascale G. 01 May 2017 (has links)
Efficient directed migration requires tight regulation of chemoattractant signal transduction pathways in both space and time, but the mechanisms involved in such regulation are not well understood. Here, we investigated the role of protein kinase A (PKA) in controlling signaling of the chemoattractant cAMP in Dictyostelium discoideum. We found that cells lacking PKA display severe chemotaxis defects, including impaired directional sensing. Although PKA is an important regulator of developmental gene expression, including the cAMP receptor cAR1, our studies using exogenously expressed cAR1 in cells lacking PKA, cells lacking adenylyl cyclase A (ACA) and cells treated with the PKA-selective pharmacological inhibitor H89, suggest that PKA controls chemoattractant signal transduction, in part, through the regulation of RasG, Rap1 and TORC2. As these pathways control the ACA-mediated production of intracellular cAMP, they lie upstream of PKA in this chemoattractant signaling network. Consequently, we propose that the PKA-mediated regulation of the upstream RasG, Rap1 and TORC2 signaling pathways is part of a negative feedback mechanism controlling chemoattractant signal transduction during Dictyostelium chemotaxis.
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Directional sensing and chemotaxis in eukaryotic cells - a quantitative study / Directional Sensing und Chemotaxis eukaryotischer Zellen - eine quantitative StudieAmselem, Gabriel 13 October 2010 (has links)
No description available.
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