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Extracellular S100A4 induces human thyroid cancer cell migrationMedapati, Manoj Reddy 28 August 2013 (has links)
Human thyroid cancer is the most commonly occurring cancer of the endocrine gland having good survival rate, but some patients show recurrence with an invasive phenotype and treatment failures. The mechanisms behind this invasive phenotype are not well understood in TC. Previously our group has identified a pro-migratory role of relaxin-like peptides in thyroid cancer that is mediated by S100A4. We have observed in human TC cells that extracellular S100A4 induces migration and activates ERK1/2, JNK/SAPK and NFkB signaling pathways. Employing immunohistochemistry and immunofluorescence we have identified the expression of RAGE in human TC primary cells, cell lines, and in tumor tissues but not in normal thyroid tissues. We showed that S100A4 binds to RAGE in TC cells and that RAGE and its cytoplasmic partner Dia-1 mediate the S100A4-induced migration of TC cells. This study identified a crucial role of RAGE in TC cell migration induced by S100A4.
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Extracellular S100A4 induces human thyroid cancer cell migrationMedapati, Manoj Reddy 28 August 2013 (has links)
Human thyroid cancer is the most commonly occurring cancer of the endocrine gland having good survival rate, but some patients show recurrence with an invasive phenotype and treatment failures. The mechanisms behind this invasive phenotype are not well understood in TC. Previously our group has identified a pro-migratory role of relaxin-like peptides in thyroid cancer that is mediated by S100A4. We have observed in human TC cells that extracellular S100A4 induces migration and activates ERK1/2, JNK/SAPK and NFkB signaling pathways. Employing immunohistochemistry and immunofluorescence we have identified the expression of RAGE in human TC primary cells, cell lines, and in tumor tissues but not in normal thyroid tissues. We showed that S100A4 binds to RAGE in TC cells and that RAGE and its cytoplasmic partner Dia-1 mediate the S100A4-induced migration of TC cells. This study identified a crucial role of RAGE in TC cell migration induced by S100A4.
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Quantitative image analysis for prognostic prediction in lung SBRT / 肺定位放射線治療における予後予測に向けた定量的画像解析Kakino, Ryo 23 March 2021 (has links)
京都大学 / 新制・課程博士 / 博士(人間健康科学) / 甲第23121号 / 人健博第83号 / 新制||人健||6(附属図書館) / 京都大学大学院医学研究科人間健康科学系専攻 / (主査)教授 椎名 毅, 教授 藤井 康友, 教授 平井 豊博 / 学位規則第4条第1項該当 / Doctor of Human Health Sciences / Kyoto University / DFAM
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Polymorphous Low-Grade CarcinomaKlijanienko, Jerzy, Al-Abbadi, Mousa A. 09 March 2011 (has links)
No description available.
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Standardized Diagnostic Workup and Patient-Centered Decision Making for Surgery and Neck Dissection Followed by Risk-Factor Adapted Adjuvant Therapy Improve Loco-Regional Control in Local Advanced Oral Squamous Cell CarcinomaWichmann, Gunnar, Pavlychenko, Mykola, Willner, Maria, Halama, Dirk, Kuhnt, Thomas, Kluge, Regine, Gradistanac, Tanja, Fest, Sandra, Wald, Theresa, Lethaus, Bernd, Dietz, Andreas, Wiegand, Susanne, Zebralla, Veit 30 March 2023 (has links)
Background: Standardized staging procedures and presentation of oral squamous cell
carcinoma (OSCC) patients in multidisciplinary tumor boards (MDTB) before treatment
and utilization of elective neck dissection (ND) are expected to improve the outcome,
especially in local advanced LAOSCC (UICC stages III–IVB). As standardized diagnostics
but also increased heterogeneity in treatment applied so far have not been demonstrated
to improve outcome in LAOSCC, a retrospective study was initiated.
Methods: As MDTB was introduced into clinical routine in 2007, 316 LAOSCC patients
treated during 1991-2017 in our hospital were stratified into cohort 1 treated before
(n=104) and cohort 2 since 2007 (n=212). Clinical characteristics, diagnostic procedures
and treatment modality of patients were compared using Chi-square tests and outcome
analyzed applying Kaplan-Meier plots and log-rank tests as well as Cox proportional
hazard regression. Propensity scores (PS) were used to elucidate predictors for impaired
distant metastasis-free survival (DMFS) in PS-matched patients.
Results: Most patient characteristics and treatment modalities applied showed
insignificant alteration. Surgical treatment included significantly more often resection of
the primary tumor plus neck dissection, tracheostomy and percutaneous endoscopic
gastrostomy tube use. Cisplatin-based chemo-radiotherapy was the most frequent. Only
insignificant improved disease- (DFS), progression- (PFS) and event-free (EFS) as well as
tumor-specific (TSS) and overall survival (OS) were found after 2006 as local (LC) and locoregional
control (LRC) were significantly improved but DMFS significantly impaired.
Cox regression applied to PS-matched patients elucidated N3, belonging to cohort 2 and
cisplatin-based chemo-radiotherapy as independent predictors for shortened DMFS. The
along chemo-radiotherapy increased dexamethasone use in cohort 2 correlates with
increased DM.
Conclusions: Despite standardized diagnostic procedures, decision-making considering
clear indications and improved therapy algorithms leading to improved LC and LRC,
shortened DMFS hypothetically linked to increased dexamethasone use had a detrimental
effect on TSS and OS.
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