Doctor Pharmaceuticae - Dpharm / Among neurological disorders, many of the most devastating disorders are neurodegenerative. Modern research associates excitotoxicity to a variety of neuropathological conditions, suggesting that the neurodegenerative diseases with distinct etiologies may have excitotoxicity as a common pathway. Excitotoxicity occurs through over-stimulation of receptors for excitatory neurotransmitters like the N-methyl-D-aspartate (NMDA) receptors. Due to the relevance of NMDA receptors and excitotoxic processes, the antagonism or modulation of NMDA receptors is used as a therapeutic tool against neurodegenerative diseases. NMDA receptor activity can be modulated by S-nitrosylation and this modulation of NMDA receptor activity can be utilised in the development of neuroprotective drugs.

The presented work aims to map the trends in the development and professionalization of foundations on the background of the civil society that was formed in the Czech Republic after 1989. It addresses the importance of endowment and appreciation of foundation assets in the long-term perspective and describes the circumstances that led to the creation of the Foundation Investment Fund (NIF). It also tries to follow the legislative and economic conditions for the development of the Czech endowment sector. In this sense the paper aims to bring some contribution to the civil society studies. Through a case study on The Committee of Good Will - The Olga Havel Foundation the thesis deals with the causes, effects and changes of the foundation's professionalization process. The research uses the means of internal and external document analysis, interviews with the foundation representatives and the method of participating observation. The effects of the professionalization process have manifested in personnel management changes (eg. recruitment of paid employees, hiring external professionals), project management changes and overall change in the scope of the foundation's activities. The foundation also took necessary steps towards better appreciation of its assets, proper care of its existing donors and...

In my theses I focus on analysis of three international private market companies. Company GEFCO ČESKÁ REPUBLIKA s.r.o. , Dalkia a.s. a ABB a.s. With this companies I'm interested in the way how they practice corporate social responsibility (CSR). When I was choosing this companies I considered facts as: Company has to have head quarter in Western Europe Company has to have experience with corporate social responsibility and has to practice CSR and has to organize social responsible activities. All chosen companies are leaders in its business sector. In my theses I will focus on overview about CSR activities of companies, mainly on corporate philanthropy. I will focus on cooperation of these companies and non government organization, I'm interested in concrete activities done by NGOs in cooperation with through CSR and how NGOs perceived activities that are done through CSR. I'm interested in the way how companies involve their employees into CSR. I 'm going to aim if subsidiaries and head quarters practice same CSR activities and using same CSR tools. I'm also interested in the role of CSR in marketing strategy of these companies. Key words Non government organization, corporate social responsibility (CSR), corporate philanthropy, corporate volunteering, volunteer, civil society, organization,...

The aim of this thesis is to describe and evaluate the current situation regarding the funding of public libraries in the Czech Republic. The introduction comprises a concise definition of the legislative framework for funding public libraries. In the main section of the work the author deals with the system of libraries providing public library and information services and how these libraries can be established. Then the analysis of the financial resources that can be used by these libraries follows, i.e. grants by founders, national and international programs and projects to support libraries, fundraising, donating, sponsoring, patronage, volunteering, grants by foundations, libraries' own business. There is also a description of pricing and financial policy, analysis of the financial management of libraries in various regions and the influence of the economic crisis on library budgets. The main part of the thesis related to the whole Czech Republic is followed by the part aimed only at the Central Bohemian. For analysis and description of financial resources and opportunities The Central Bohemian Research Library in Kladno, contributory organization has been selected. The analytical part is complemented by experiences of other selected libraries, i.e. The Municipal Library in Žilina and The Town...

Imidazolium-based ionic liquids are very popular for different applications because of their low viscosity and melting point. However, the hydrogen atom at the C2 position of the imidazolium cation can easily be deprotonated by a base, resulting in a reactive carbene. If an inert ionic liquid is needed, it is necessary to introduce an unreactive alkyl or aryl group at the C2 position to prevent deprotonation. Tunable aryl alkyl ionic liquids (TAAILs) were first introduced by our group in 2009 and are characterized by a phenyl group at the N1 position, which offers the possibility to fine-tune the physicochemical properties by using different electron-donating or -withdrawing substituents. In this work, we present a new series of TAAILs where the C2 position is blocked by a methyl, propyl or phenyl group. For each of the blocking groups, the phenyl and three different phenyl derivatives (2-Me, 4-OMe, 2,4-F₂) are compared with respect to melting point, viscosity, conductivity and electrochemical window. In addition, the differences between blocked and unblocked TAAILs with regard to their electrochemical reduction potentials are investigated by quantum chemical methods.