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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

Molecular characterization of double-stranded (ds) RNAs in Chalara elegans and biological effects on the fungus /

Park, Yunjung. January 1900 (has links)
Thesis (Ph.D.) - Simon Fraser University, 2004. / Theses (Dept. of Biological Sciences) / Simon Fraser University. Bibliography : leaves 134-154.
2

Quinic acid-mediated induction of hypovirulence and a hypovirulence-associated double-stranded RNA in Rhizoctonia solani /

Liu, Chunyu, January 2001 (has links)
Thesis (Ph. D.) in Biochemistry and Molecular Biology--University of Maine, 2001. / Includes vita. Includes bibliographical references (leaves 71-83).
3

Double-stranded RNA induced gene silencing of neuropeptide genes in sand shrimp, Metapenaeus ensis and development of crustacean primary cell culture /

Guan, Haoji. January 2006 (has links)
Thesis (M. Phil.)--University of Hong Kong, 2006. / Title proper from title frame. Also available in printed format.
4

Double-stranded RNA induced gene silencing of neuropeptide genes in sand shrimp, metapenaeus ensis and development of crustacean primary cell culture /

Guan, Haoji. January 2006 (has links)
Thesis (M. Phil.)--University of Hong Kong, 2006. / Also available online.
5

1) Improving the uptake and retention of gadolinium in tumors for potential gadolinium-neutron capture therapy : Integration of gemcitabine or localized irradiation into dsRNA therapy significantly enhanced the resultant anti-tumor activity /

Le, Uyen Minh. January 1900 (has links)
Thesis (Ph. D.)--Oregon State University, 2009. / Printout. Titles called 1 and 2. Includes bibliographical references (leaves 174-197). Also available on the World Wide Web.
6

Analysis of an anti-silencing mechanism involved in immune evasion by vector-borne dsRNA animal viruses of family Reoviridae

Belhouchet, Mourad January 2013 (has links)
No description available.
7

Role of Macrophage Scavenger Receptor 1 and Extracellular Double-Stranded RNA in Antiviral Cell Signaling / Antiviral Signaling Mechanisms of Extracellular dsRNA

Baid, Kaushal January 2021 (has links)
Recognition of non-self, pathogen-associated molecular patterns is a central component of host immune response to pathogens like viruses. Intracellular detection of viral nucleic acids leads to the production of type I interferons (IFN-I) and subsequent establishment of an antiviral state in infected and neighboring cells. Viruses have evolved multiple mechanisms to counteract IFN-I responses in infected cells, however, viral nucleic acids released from dying cells can stimulate IFN-I production in surrounding or distal uninfected cells. This thesis examines the mechanisms by which cells recognize extracellular viral nucleic acids and the subsequent downstream antiviral signaling. Class A scavenger receptors (SR-As) internalize extracellular viral double-stranded RNA (dsRNA) to mediate IFN-I responses, but little is known about extracellular viral DNA. We observed that extracellular DNA is recognized and internalized by SR-As in a manner like extracellular dsRNA. Furthermore, we established that SR-A1 is sufficient in mediating extracellular dsRNA-induced cellular responses and other nucleic acid receptors like SR-J1 and DEC-205 are dispensable. Finally, a direct interaction of RNA and DNA species was demonstrated with the coiled-coil collagenous domain of SR-A1, but not the scavenger receptor cysteine rich domain of SR-A6.We elaborated the role of SR-A1 by identifying the cellular processes activated through SR-A1 following uptake of extracellular dsRNA. Cytosolic sensors are essential in mediating an antiviral response to the endocytosed dsRNA, but the mechanism of endoplasmic release and cytoplasmic entry of dsRNA remains an enigma. We demonstrated that the lack of a dsRNA-channel, SIDT2, impaired the ability of the cells to mediate an antiviral response to extracellular dsRNA. Understanding host responses to extracellular viral nucleic acids will enable the development of novel vaccines and antiviral therapeutics against RNA and DNA viruses that efficiently counteract these responses in infected cells. / Thesis / Doctor of Philosophy (PhD) / Viral infections remain a threat to global health as new diseases continue to emerge. To develop effective vaccines and antivirals to combat viruses and alleviate human disease require a deeper understanding of virus-host interactions. Host cells identify virus-associated molecules to detect viruses and eliminate them whereas, viruses employ tactics to prevent the activation of the immune system. However, virus-induced cell lysis releases viral molecules that can stimulate immune responses in neighbouring uninfected cells. This thesis examines the mechanism by which cells respond to extracellular viral nucleic acids. We showed that a protein present at the cell surface called ‘class A scavenger receptor 1’ is sufficient to internalize extracellular viral nucleic acids, leading to immune responses. The response is impaired when a channel protein, SIDT2, is absent in the cells. Further work is necessary to understand how this knowledge can be harnessed to develop vaccines and antiviral therapeutics.
8

Human Prostate Cancer Cell Apoptosis Induced by Interferon-γ and Double-Stranded RNA and Studies on the Biological Roles of Transmembrane and Coiled-Coil Domains 1

Tan, Haiyan 23 August 2010 (has links)
No description available.
9

Double-stranded RNA induced gene silencing of neuropeptide genes in sand shrimp, Metapenaeus ensis and development of crustacean primarycell culture

Guan, Haoji., 關浩基. January 2006 (has links)
published_or_final_version / abstract / Zoology / Master / Master of Philosophy
10

Deciphering the molecular mechanism by which Fml1 promotes and constrains homologous recombination

Nandi, Saikat January 2011 (has links)
Homologous Recombination (HR) can promote genome stability through its capacity to faithfully repair DNA gouble 2trand !;!reak2 (DSBs) and preventing the demise of stalled replication forks in part by catalysing template switching to enable DNA polymerase to bypass lesions. Despite these beneficial roles, inappropriate or untimely HR events can have deleterious consequences. HR can cause genome instability by recombining "inappropriate" homologous sequences, especially if the recombination intermediates are resolved to form crossovers. Over the past few years, study of the rare inherited chromosome instability disorder, Eanconi Anaemia (FA), has uncovered a novel DNA damage response pathway. Although the FA pathway is required primarily for interstrand DNA cross link repair, its precise role in DNA repair reactions is still unclear. FA.Qomplementation group M (FANCM) is the sole component within the FA core complex which possesses a DNA helicase/ATPase domain and an endonuclease domain (albeit non-functional), suggesting that FANCM could translocate along DNA and target the FA core complex to blocked replication forks. To further elucidate the role of FANCM in HR, I have purified Fm11, the FANCM orthologue in the fission yeast Schizosaccharomyces pombe and tested its activity on a range of synthetic replication and recombination intermediates in vitro. Fml1 binds both replication forks and Holliday Junctions (HJs) which are key intermediates of HR.

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