This research was conducted to 1) evaluate the use of drain tile (subsurface drainage) in an irrigated and dryland management system in both a cotton and soybean production system and 2) determine an herbicide program to control Palmer amaranth (Amaranthus palmeri S. Wats.) in the absence of dicamba. Neither drainage or drainage spacing had any effect pre-plant soil conditions, plant growth parameters, or yield in either production system. Stand counts were reduced in narrow tiled spacings (4.5 m) in the dryland cotton study. However, there was no reduction in lint yield due to the reduction in plant stand. Moreover, residual control was maximized with the use of fluridone and fomesafen as PRE emergence treatments. Glufosinate provided the greatest control of Palmer amaranth in the absence of dicamba. Lint yield was maximized with the application of glufosinate in the absence of dicamba. These data indicate that subsurface drainage had no effect on cotton or soybean performance in Mississippi. Moreover, in the absence of dicamba Palmer amaranth control options can be optimized by using fluridone or fomesafen as PRE emergence applications and glufosinate as POST emergence application to minimize yield reductions due to Palmer amaranth.