- About
-
The Global ETD Search service is a free service for researchers
to find electronic theses and dissertations. This service is
provided by the
Networked Digital Library of Theses and Dissertations.
Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
Search results
Showing 181 to 190 of 10704 (0.029 seconds)| 181 |
Caco-2 cell model : characterization, transport and permeability studies and intracellular secretory mechanismsHassan, Ian Francis January 1990 (has links)
No description available.
|
| 182 |
The role of angiotensin in the control of blood pressure : a functional interaction with the autonomic nervous systemHatton, R. January 1987 (has links)
An interaction of the renin-angiotensin system and the autonomic nervous system was demonstrated in vivo during activation of the former by sodium depletion in the dog and the latter during application of lower body negative pressure (LBNP) in the cat. In the dog, inhibitors of angiotensin converting enzyme (ACE), teprotide and captopril, together with an angiotensin II (AII) antagonist, saralasin, and a peptide inhibitor of renin, H77, given intravenously lowered blood pressure (BP) by reducing peripheral resistance in relation to the prevailing level of plasma renin activity (PRA). They did so without changing cardiac output or heart rate as PRA rose above the resting level. The lack of tachycardia was due to a resetting of the baroreflex without a change in sensitivity as teprotide unmasked an action of AII at a peripheral site since when administered into a lateral cerebral ventricle it was ineffective. In the cat, teprotide and saralasin enhanced the fall in BP induced by LBNP and impaired its recovery. When these inhibitors were given during LBNP, a greater and more sustained fall in BP was seen than with either inhibitor alone. This occurred before activation of plasma renin and was not associated with a reduction in sympathetic efferent nerve activity. Further studies revealed that teprotide, captopril and enalapril interfered with neurogenic vasoconstriction involving AII in pithed rats and moreover, captopril was active in lowering BP in two strains of rat shown to be particularly sensitive to the adrenergic potentiating effect of AII. These findings have provided physiological evidence in vivo supporting a peripheral interaction between the autonomic nervous system and AII even at low levels of activation which potentiate adrenergic mechanisms and maintain homeostatic reflexes. They suggest that a significant part of the hypotensive activity of ACE inhibitors is due to interference with facilitatory actions of AII on the autonomic nervous system.
|
| 183 |
The development and evaluation of a full-text drugs database Martindale onlineReynolds, J. E. F. January 1987 (has links)
No description available.
|
| 184 |
The synthesis of potential anticonvulsants via 2-chloroamidesDa Costa, Neil C. January 1992 (has links)
No description available.
|
| 185 |
Isolated hepatocytes as a model for ranitidine metabolism : in vivo and in vitro correlations in the rat, dog and guinea pigCross, David Michael January 1991 (has links)
No description available.
|
| 186 |
Psychopharmacological effects of +-3, 4-methylenedioxymetamphetamine (MDMA, 'Ecstacy') : mood and cognitive function in current and ex-usersVerheyden, Suzanne Louise January 2001 (has links)
No description available.
|
| 187 |
Gastrointestinal transit of multiple unit dosage formsDevereux, Jane Elizabeth January 1987 (has links)
No description available.
|
| 188 |
The development of high resolution techniques for the surveillance of medicinesWaters, Robert Kenneth January 2001 (has links)
No description available.
|
| 189 |
Studies on microspheres designed for oral uptake : biocompatibility, binding and uptake mechanismsCarreno-Gomez, Begona January 1999 (has links)
No description available.
|
| 190 |
Liposomes in drug delivery : site-directed approaches using active and passive targetingSenior, Judith Helen January 1989 (has links)
No description available.
|
Page generated in 0.0339 seconds