This webinar will describe East Tennessee State University’s efforts to curb the opioid epidemic along the continuum of addiction. ETSU’s Academic Health Science Center has engaged multiple constituents to conduct federally funded research, community based practice and more importantly, to foster cross-sector engagement and education. The team hosts monthly meetings to facilitate partnerships across sectors with multiple aims. These aims include regional health improvement, research capacity development and community outreach. By the end of this webinar, participants will be able to: Describe multiple evidence-based approaches for the prevention and treatment of opioid use disorder. Describe techniques for engagement in community and cross-sector collaboration to address the opioid use disorder crisis.