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Mechanism of electron transfer in double-stranded DNA and PNA-DNA hybrids, and the development of a fluorescence probe for DNA and RNA detectionLy, Danith 12 1900 (has links)
No description available.
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Thiophene : alkylthiophene copolymers from substituted oligothiophenesHenderson, Paul Thomas 12 1900 (has links)
No description available.
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Role of Base and nucleotide excision repair pathways in processing of clustered DNA lesions induced by ionising radiationBudworth, Helen Louise January 2003 (has links)
Ionising radiation (IR) induces a wide spectrum of lesions in DNA, including double- and single-strand breaks, abasic (AP) sites and a variety of base lesions. IR-induced damage to DNA can range from simple, isolated lesions to clustered DNA damage in which multiple lesions are formed, usually within a single helical turn of the DNA. Individual lesions within a cluster are recognised by repair enzymes of the base excision repair (BER) pathway, however, clustered DNA damage may be recognised as a bulky lesion and be processed by nucleotide excision repair (NER). Additionally, the presence of other closely spaced lesions may affect the rate and fidelity of DNA repair and, in doing so, may contribute to the harmful effects of ionising radiation. The aim of this study is to gain further understanding of the repairability of clustered DNA damage and the effects of multiple lesions on cellular repair systems. 7, 8-dihydro-8-oxoguanine (8-oxoG), thymine glycol (Tg), AP sites and single-strand breaks (SSB), some of the most frequently formed IR-induced DNA lesions, were employed in synthetic oligonucleotides to model various types of clustered lesions and their repairability was studied using purified base excision repair enzymes and cell extracts. It was revealed that BER is the major repair system involved in the processing of clustered DNA lesions, and that some clustered lesions are repaired with decreased efficiency. Both the composition of lesions in a cluster and the positioning of the various lesions determine their repairability by base excision repair enzymes.
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The role of RAD51-like genes in the repair of DNA damage in mammalian cellsFrench, Catherine A. January 2003 (has links)
No description available.
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Ultra-high resolution DNA crystallographyMaehigashi, Tatsuya 19 May 2009 (has links)
This thesis represents results of experiments involved in ultra-high resolution x-ray crystal structures of DNA. Detailed analysis of DNA coordinates of increased accuracy, refinement of individual anisotropic B-factors, visualization of disorder, counterions and hydration are presumably facilitated by the increased information of ultra-high resolution structures. However, recent survey of available DNA crystal structures with the data that extends beyond 1Ã... has brought a few areas of considerations; local conformational flexibility of DNA and counterions and how they have been interpreted in previous studies. While the results given here demonstrate both structural and surrounding details of DNA that may be undetected at lower resolution, some of the technical aspects of interpreting ultra-high resolution data is also addressed.
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On the effect of UV-irradiation on DNA replication in Escherichia coli /Verma, Meera Mary. January 1985 (has links) (PDF)
Thesis (Ph. D.)--University of Adelaide, 1985. / Includes bibliographical references (leaves 267-287).
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257 |
Characterisation of DNA damage inducible responses and repair in human cells using recombinant adenovirus vectors /Francis, Murray A. January 2000 (has links)
Thesis (Ph.D.) -- McMaster University, 2000. / Includes bibliographical references (leaves 244-294). Also available via World Wide Web.
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258 |
A genomic screen for Zic1 target genes in neural developmentLi, Shuzhao. January 2006 (has links) (PDF)
Thesis (M.S.)--Montana State University--Bozeman, 2006. / Typescript. Chairperson, Graduate Committee: Christa Merzdorf. Includes bibliographical references (leaves 51-55).
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259 |
Systematics, mating compatibility, and ribosomal DNA variation in Agrocybe section Pediadeae /Rehner, Stephen Austin. January 1989 (has links)
Thesis (Ph. D.)--University of Washington, 1989. / Vita. Includes bibliographical references (leaves [83]-90).
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260 |
Electrospray ionisation mass spectrometry of biomolecular complexesGupta, Rajesh. January 2003 (has links)
Thesis (Ph.D)--University of Wollongong, 2003. / Typescript. Includes bibliographical references: leaf 210-234.
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