Although household product, such as pharmaceuticals and cleaning chemicals, are part of a child’s everyday life, accidental poisonings can occur as a result of ingestion. Children diagnosed with developmental disabilities are even more susceptible to being injured when they come into contact with these poisonous agents. Behavioral approaches have been used extensively to teach safety skills to children with disabilities. However, those that targeted poison prevention skills required additional methods that were more intrusive for the child to acquire the skills. Thus, the purpose of this study was to evaluate the efficacy of a modified behavioral skills training package that incorporates a system of least prompts. Results showed that BST and system of least prompts increased poison prevention skills for all three participants and the skills maintained at follow-up.