This dissertation draws attention to covert efforts directed at African women that seek to negatively affect the family structure and the historic cultural value systems, thereby destabilizing the African family setting, and destroying the society through a process of depopulation in Etsako in Edo State, and by extension, Nigeria and Africa. The researcher employed the African philosophy of politics and government as the conceptual framework most suitable for this research. The American woman’s knowledge of the African woman was investigated. Equally, the African woman was examined to determine what she thinks of her womanhood role. The findings established that the struggle for political development of the African woman is pregnant with meaning, as it is a vital aspect of some of the covert and overt influence of the West directed at the Africans’ root of existence. Other finding include the following: 1. That the Western World has targeted the entire population of Etsako, Nigeria and Africa by an extension, for a political resocialization that is alien to the people of Africa. 2. That the American woman has limited knowledge of the African woman. 3. That in the effort to adversely influence the African woman, some African American women of the intelligentsia are unknowingly being used to facilitate some of the covert efforts. 4. That the African women appreciates her womanhood roles in the home front and her external relations; and, 5.that the African woman’s political efficacy, from a Western political framework, in the African political systems, will destroy the traditional family structure, the cultural and moral basis of the people. This will further destroy the historic African cultural value systems and, eventually lead to a moral void and the collapse of these societies. Deviant behavior and deliberate depopulation will trigger the collapse. The study, therefore, recommends among other things that to prevent such cultural destabilization, the Etsako people and possibly, Nigeria need to educate and politically socialize their women, from an African socio-cultural political framework. This is a major way by which Etsako and Africa by extension will command Western political respect.