The design and development of wearable inertial sensor systems for health monitoring has garnered a huge attention in the scientific community and the industry during the last years. Such platforms have a typical architecture and common building blocks to enable data collection, data processing and feedback restitution. In this thesis we analyze power optimization techniques that can be applied to such systems. When reducing power consumption in a wearable system, different trade-offs have to be inevitably faced. We thus propose software techniques that span from well known duty cycling, frequency scaling, data compression to new paradigm such as radio triggering, heterogeneous multi-core and context aware power management.

The negotiation between power consumption, performance, programmability, and portability drives all computing industry designs, in particular the mobile and embedded systems domains. Two design paradigms have proven particularly promising in this context: architectural heterogeneity and many-core processors. Parallel programming models are key to effectively harness the computational power of heterogeneous many-core SoC. This thesis presents a set of techniques and HW/SW extensions that enable performance improvements and that simplify programmability for heterogeneous many-core platforms. The thesis contributions cover vertically the entire software stack for many-core platforms, from hardware abstraction layers running on top of bare-metal, to programming models; from hardware extensions for efficient parallelism support to middleware that enables optimized resource management within many-core platforms. First, we present mechanisms to decrease parallelism overheads on parallel programming runtimes for many-core platforms, targeting fine-grain parallelism. Second, we present programming model support that enables the offload of computational kernels within heterogeneous many-core systems. Third, we present a novel approach to dynamically sharing and managing many-core platforms when multiple applications coded with different programming models execute concurrently. All these contributions were validated using STMicroelectronics STHORM, a real embodiment of a state-of-the-art many-core system. Hardware extensions and architectural explorations were explored using VirtualSoC, a SystemC based cycle-accurate simulator of many-core platforms.

To enable a new generation of digital computing applications, the greatest challenge is to provide a better level of energy efficiency (intended as the performance that a system can provide within a certain power budget) without giving up a systems's flexibility. This constraint applies to digital system across all scales, starting from ultra-low power implanted devices up to datacenters for high-performance computing and for the "cloud". In this thesis, we show that architectural heterogeneity is the key to provide this efficiency and to respond to many of the challenges of tomorrow's computer architecture - and at the same time we show methodologies to introduce it with little or no loss in terms of flexibility. In particular, we show that heterogeneity can be employed to tackle the "walls" that impede further development of new computing applications: the utilization wall, i.e. the impossibility to keep all transistors on in deeply integrated chips, and the "data deluge", i.e. the amount of data to be processed that is scaling up much faster than the computing performance and efficiency. We introduce a methodology to improve heterogeneous design exploration of tightly coupled clusters; moreover we propose a fractal heterogeneity architecture that is a parallel accelerator for low-power sensor nodes, and is itself internally heterogeneous thanks to an heterogeneous coprocessor for brain-inspired computing. This platform, which is silicon-proven, can lead to more than 100x improvement in terms of energy efficiency with respect to typical computing nodes used within the same domain, enabling the application of complex algorithms, vastly more performance-hungry than the current state-of-the-art in the ULP computing domain.

Performance and energy consumption in modern computing platforms is largely dominated by the memory hierarchy. The increasing computational power in the multiprocessors and accelerators, and the emergence of the data-intensive workloads (e.g. large-scale graph traversal and scientific algorithms) requiring fast transfer of large volumes of data, are two main trends which intensify this problem by putting even higher pressure on the memory hierarchy. This increasing gap between computation speed and data transfer speed is commonly referred as the “memory wall” problem. With the emergence of heterogeneous Three Dimensional (3D) Integration based on through-silicon-vias (TSV), this situation has started to recover in the past years. On one hand, it is now possible to improve memory access bandwidth and/or latency by either stacking memories directly on top of processors or through abstracted memory interfaces such as Micron’s Hybrid Memory Cube (HMC). On the other hand, near memory computation has become worthy of revisiting due to the cost-effective integration of logic and memory in 3D stacks. These two directions bring about several interesting opportunities including performance improvement, energy and cost reduction, product miniaturization, and modular design for improved time to market. In this research, we study the effectiveness of the 3D integration technology and the optimization opportunities which it can provide in the different layers of the memory hierarchy in cluster-based many-core platforms ranging from intra-cluster L1 to inter-cluster L2 scratchpad memories (SPMs), as well as the main memory. In addition, by moving a part of the computation to where data resides, in the 3D-stacked memory context, we demonstrate further energy and performance improvement opportunities.

The development of microlectronic lab-on-a-chip devices (LOACs) can now be pursued thanks to the continous advances in silicon technology. LOACs are miniaturized devices whose aim is to perform in a more efficient way specific chemical or biological analysis protocols which are usually carried out with traditional laboratory equipment. In this application area, CMOS technology has the potential to integrate LOAC functionalities for cell biology applications in single chips, e.g. sensors, actuators, signal conditioning and processing circuits. In this work, after a review of the state of the art, the development of a CMOS prototype chip for individual cell manipulation and detection based on dielectrophoresis will be presented. Issues related to the embedded optical and capacitive detection of cells will be discussed together with the main experimental results obtained in manipulation and detection of living cells and microparticles.

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