Downstream vehicles detect an emergency response vehicle (ERV) through sirens and/or strobe lights. These traditional warning systems do not give any recommendation about how to react, leaving the drivers confused and often adopting unsafe behavior while trying to open a passage for the ERV. In this research, an advanced intra-link emergency assistance system, that leverages the emerging technologies of the connected vehicle environment, is proposed. The proposed system assumes the presence of a centralized system that gathers/disseminates information from/to connected vehicles via vehicle-to-infrastructure (V2I) communications. The major contribution of this dissertation is the intra-link level support provided to ERV as well as non-ERVs. The proposed system provides network-wide assistance as it also considers the routing of ERVs. The core of the system is a mathematical program - a set of equations and inequalities - that generates, based on location and speed data from connected vehicles that are downstream of the ERV, the fastest intra-link ERV movement. It specifies for each connected non-ERV a final assigned position that the vehicle can reach comfortably along the link. The system accommodates partial market penetration levels and is applicable on large transportation link segments with signalized intersections. The system consists of three modules (1) an ERV route generation module, (2) a criticality analysis module and (2) the sequential optimization module. The first module determines the ERV's route (set of links) from the ERV's origin to the desired destination in the network. Based on this selected route, the criticality analysis module scans/filters the connected vehicles of interest and determines whether any of them should be provided with a warning/instruction message. As the ERV is moving towards its destination, new non-ERVs should be notified. When a group of non-ERVs is identified by the criticality analysis module, a sequential optimization module is activated. The proposed system is evaluated using simulation under different combinations of market penetration and congestion levels. Benefits in terms of ERV travel time with an average reduction of 9.09% and in terms of vehicular interactions with an average reduction of 35.46% and 81.38% for ERV/non-ERV and non-ERV/non-ERV interactions respectively are observed at 100% market penetration, when compared to the current practice where vehicles moving to the nearest edge. / Doctor of Philosophy / Downstream vehicles detect an emergency response vehicle (ERV) through sirens and/or strobe lights. These traditional warning systems do not give any recommendations about how to react, leaving the drivers confused and often adopting unsafe behavior while trying to open a passage for the ERV. In this research, an advanced intra-link emergency assistance system, that leverages the emerging technologies of the connected vehicle environment, is proposed. The proposed system assumes the presence of a centralized system that gathers/disseminates information from/to connected vehicles via vehicle-to-infrastructure (V2I) communications. The major contribution of this dissertation is the intra-link level support provided to ERV as well as non-ERVs. The proposed system provides network-wide assistance as it also considers the routing of ERVs. The core of the system is a mathematical program - a set of equations and inequalities - that generates, based on location and speed data from connected vehicles that are downstream of the ERV, the fastest intra-link ERV movement. It specifies for each connected non-ERV a final assigned position that the vehicle can reach comfortably along the link. The system accommodates partial market penetration levels and is applicable on large transportation link segments with signalized intersections. The system consists of three modules (1) an ERV route generation module, (2) a criticality analysis module and (2) the sequential optimization module. The first module determines the ERV’s route (set of links) from the ERV’s origin to the desired destination in the network. Based on this selected route, the criticality analysis module scans/filters the connected vehicles of interest and determines whether any of them should be provided with a warning/instruction message. As the ERV is moving towards its destination, new non-ERVs should be notified. When a group of non-ERVs is identified by the criticality analysis module, a sequential optimization module is activated. The proposed system is evaluated using simulation under different combinations of market penetration and congestion levels. Benefits in terms of ERV travel time with an average reduction of 9.09% and in terms of vehicular interactions with an average reduction of 35.46% and 81.38% for ERV/non-ERV and non-ERV/non-ERV interactions respectively are observed at 100% market penetration, when compared to the current practice where vehicles moving to the nearest edge.