Submitted by Automa??o e Estat?stica (sst@bczm.ufrn.br) on 2018-01-18T10:52:22Z No. of bitstreams: 1 IaraDantasDeSouza_DISSERT.pdf: 2361022 bytes, checksum: 9a172e308a03ac6a5069e610ed9829b8 (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2018-01-22T15:02:53Z (GMT) No. of bitstreams: 1 IaraDantasDeSouza_DISSERT.pdf: 2361022 bytes, checksum: 9a172e308a03ac6a5069e610ed9829b8 (MD5) / Made available in DSpace on 2018-01-22T15:02:53Z (GMT). No. of bitstreams: 1 IaraDantasDeSouza_DISSERT.pdf: 2361022 bytes, checksum: 9a172e308a03ac6a5069e610ed9829b8 (MD5) Previous issue date: 2017-12-14 / Desde a antiguidade, o chumbo (Pb) vem sendo utilizado pela humanidade em virtude das suas propriedades f?sico-qu?micas, como maleabilidade, ductilidade, resist?ncia ? corros?o, baixo ponto de fus?o e baixa condutividade el?trica. Entretanto, al?m de sua import?ncia econ?mica, o chumbo possui uma import?ncia quanto ? sa?de humana, uma vez que causa intoxica??o. Muitos efeitos da intoxica??o pelo chumbo j? foram relatados na literatura, sendo respons?vel pela toxicidade nos sistemas cardiovascular, imunol?gico, ?sseo, reprodutivo, hematopoi?tico, renal, gastrointestinal e, principalmente, no sistema nervoso. Embora haja evid?ncias sobre como o chumbo afeta a homeostase em n?vel celular, a descri??o das vias metab?licas afetadas na intoxica??o por chumbo n?o est? estabelecida. Para esclarecer os efeitos da intoxica??o, o objetivo deste estudo ? propor vias metab?licas das intera??es do chumbo com os componentes celulares, atrav?s da curadoria das informa??es presentes na literatura e em reposit?rios p?blicos. Ap?s a busca na literatura, encontramos um total de 23 prote?nas, incluindo o tripept?deo glutationa, as quais s?o capazes de interagir com o chumbo e est?o relacionadas com a base celular da intoxica??o. Estas informa??es, em conjunto com outras provenientes de reposit?rios especializados, permitiram a integra??o do conhecimento em uma via metab?lica da intoxica??o por chumbo. Por meio dela, observou-se que o chumbo atua de maneira sist?mica no organismo, em especial, interferindo na fun??o normal de prote?nas as quais se ligam a metais essenciais, como zinco e c?lcio. / Since ancient times, lead (Pb) has been used by mankind because of its physicochemical properties, such as malleability, ductility, corrosion resistance, low melting point and low electrical conductivity. However, in addition to its economic importance, lead is an important human health issue since it causes intoxication. Many effects of lead intoxication have been reported in the literature, affecting the organism as a whole and causing symptoms in cardiovascular, immune, skeletal, reproductive, hematological, renal, gastrointestinal and nervous systems. Although there is evidence on how lead affects cellular homeostasis, the description of the metabolic pathways affected in lead poisoning is not fully established. To elucidate the effects of lead poisoning, the aim of this study is to propose pathways of lead interactions with cell components, through manual curation of information present in literature and public repositories. After a search in literature, it was found a total of twenty-three proteins, including glutathione, which can directly interact with lead and are related to the cellular basis of intoxication. This knowledge taken together with the information present in pathways repositories allowed the integration of the current information in a map of lead poisoning. It was observed that lead acts in a systemic way, specially interfering with the normal function of metalloproteins which rely on essential metals to the organism, such as calcium and zinc.