Dans le présent travail de recherche, nous proposons d’analyser principalement l’effet direct et indirect du changement climatique sur la production agricole et la croissance économique. Pour ce faire, la voie méthodologique retenue dans cette thèse est une voie empirique, s’appuyant à la fois sur l’économétrie spatiale, la technique de cointégration sur données de panel ainsi que le modèle d’équilibre général dynamique multisectoriel / The aim of this research is to analysis both direct and indirect effect of the climate change on the agricultural production and the economic growth. This PhD research we will be based on an empirical methodology, through applying a spacial econometrics and the cointegration technique of a panel data as well as a multisectoral general equilibrium growth model. The first part is devoted to find the effect of the climate change on the agricultural production in a macro spatial level during the period 1980-2012. The main gaol of this first chapter of this PhD is to determine the direct and indirect effect of the weather forecast and the temperature changes in one region compared to the neighbouring regions. The originality of this spacial modelisation is to give an effective spacial effect. The second part of this research is aimed to use a micro spacial analysis to find out the effect of the climate change on the agricultural production in the long term way and for each region rather then all of them together as in the first chapter. In the last part of this PhD research we developed a general and dynamic equilibrium model for the Tunisian economy taking in a count eventual climate change forcast from 2015 to 2030. Aiming to calculate the effect of this change on the agricultural production and the economic aggregate in Tunisa. The resulats show that the climate change forecast in the futur will affect the agricultural production in Tunisia in both the short run and the long term and this is because of the irrigated and non irrigated plantations. The decrease of the production will affect the food industry which will decrease the level of the investment, the employment in this sector as well as the consumption.