Hydrogenous samples, such as biological tissues, analyzed in a neutron radiography geometry display reduced image contrast and resolution due to excessive image contributions from scattered neutrons produced from the high neutron-scatter cross section with hydrogen. Because of this, neutrons presently are not used for thick-tissue(>2.5cm) or in-vivo imaging. Two methods of neutron scatter rejection and event centroiding, were employed to enhance the quality of biological neutron imaging by reducing image blurring noise caused by hydrogen and increasing the contrast ratio of the detector. By employing the techniques used herein, event centroiding can increase the natural resolution of the detector by a factor of two without energy dependence and as much as 4 times with energy bins. Scatter rejection can increase the contrast resolution by 7%-10% of an imaging standard and can resolve a 160 μm image through 6mm of acrylic.