NDLTD Global ETD Search
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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.

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Antibiotic free and optimised protein production using Escherichia coli

Engström, Mathias, Pontén, Olle, Philip, Carlsson, Bahnam, Nadeen, Strömberg, Ella, Westlin, Oskar January 2018 (has links)
Affibody® molecules are small therapeutic proteins which mimics antibody functionality. This is a report of several methods for increasing productivity and yield in recombinant production of Affibody® molecules. This literature study shows several steps in the production line which can be optimised, several novel methods for cultivating and harvesting cells and purication of proteins. There is also a section about validation of therapeutic protein production according to The International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) are presented.
TAT
recombinant protein production
optimisation
fermentation
chromatography
protein purification
filtration
excretion system
affibody
biopharmaceuticals
validation
Industrial Biotechnology
Industriell bioteknik

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