This reserch aims to investigate the realtionship of expatriate's cross-cultural competence with his entrepreneurship. By building an integrative framework, we identify three constructs, big-five personality, cultural intellegance and cross-cultural adjustment, which were encompassed in cross-cultural competence to have associations with expatriate's entrepreneurship. Using SEM model to analyzed sample of 230 expatriates, our findings reveals that expatriate's personality has positive associations with expatriates' entrepreneurship. In addition, expatriate's personality will affect the ability to cross-cultural adjustment and cultural intelligence for entrepreneurship in their expatriate assignments to MNC's subsidiary. In short, this research proposes a cross-cultural framework to illustrate how expatriate's personality affects their cultural intelligence and cross-cultural adjustment, which act as mediators in the relationships between personality and entrepreneurship. Moreover, cultural difference is found to be an important moderator among all the relationships above entrepreneurial spirit for business performance at host.