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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
11

Clinical and immunopathological studies in Hodgkin's disease with special reference to prognosis /

Axdorph, Ulla, January 1900 (has links)
Diss. (sammanfattning) Stockholm : Karol. inst., 2001. / Härtill 5 uppsatser.
12

Gene expression profiles at the myotonic dystrophy 1 locus : possible role in disease mechanisms /

Eriksson, Maria, January 1900 (has links)
Diss. (sammanfattning) Stockholm : Karol. inst., 2001. / Härtill 4 uppsatser.
13

Expression and function of GDNF family ligands and receptors in the nervous system /

Mikaels, Åsa, January 1900 (has links)
Diss. (sammanfattning) Stockholm : Karol. inst., 2001. / Härtill 6 uppsatser.
14

Molecular biology of cell reactions to surface topography

Li, Tong-Tong January 1998 (has links)
No description available.
15

Gene expression in carcinogenesis /

Fischer, Heléne, January 1900 (has links)
Diss. (sammanfattning) Stockholm : Karol. inst., 2001. / Härtill 5 uppsatser.
16

Second messenger-mediated kinases and the control of gene expression /

Matthews, Randolph Pretlow. January 1996 (has links)
Thesis (Ph. D.)--University of Washington, 1996. / Vita. Includes bibliographical references (leaves [115]-140).
17

Structure and function of the platelet and T-cell activation antigen-1 (PTA1)

Adamson, Janet January 2000 (has links)
No description available.
18

The common basis of sympathetic nervous system and neuroblastoma development

Shi, Huilin. January 2009 (has links)
Thesis (Ph. D.)--University of Toledo, 2009. / "In partial fulfillment of the requirements for the degree of Doctor of Philosophy in Biomedical Sciences (Cancer Biology)." Title at OhioLINK ETD site: Investigation of common bases of sympathetic nervous system and neuroblastoma development. Title from title page of PDF document. Includes bibliographical references (p. 72-75, 119-125, 152-192).
19

Structural and Functional Characterization of T.thermophilus CasE

Gesner, Emily Unknown Date
No description available.
20

Structural and Functional Characterization of T.thermophilus CasE

Gesner, Emily 06 1900 (has links)
Powerful mechanisms of genetic interference in both unicellular and multicellular organisms are based on the sequence-directed targeting of DNA or RNA by small effector RNAs. In many bacteria and almost all archaea, RNAs derived from clustered, regularly interspaced, short palindromic repeat (CRISPR) loci are involved in an adaptable and heritable gene-silencing pathway. Resistance to phage infection is conferred by the incorporation of short invading DNA sequences into the prokaryotic genome as CRISPR spacer elements separated by short repeat sequences. A central aspect to this pathway is the processing of a long primary transcript (pre-crRNA) containing these repeats by crRNA endonucleases to generate the mature effector RNAs that interfere with phage or plasmid gene expression. Here we describe a structural and functional analysis of the CasE endonuclease of T. thermophilus a member of the Ecoli CRISPR sub-type. High resolution X-ray structures of CasE bound to repeat RNAs model both the pre-and post-cleavage complexes associated with processing the pre-crRNA. These structures establish the molecular basis of a specific CRISPR RNA recognition and suggest the mechanism for generation of effector RNAs responsible for gene-silencing.

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