Purpose: Sustainability and reduced environmental impact are increasingly pressing challenges within the construction sector. Wood has become a sought-after building material due to its renewability and lower energy intensity during manufacturing. However, the growing demand for buildings coupled with diminishing available land has led to vertical construction emerging as a solution. Multi-story buildings that primarily utilize wood as their construction material, however, face a range of challenges, including fire hazards, moisture-related issues, and requirements for strong connections between various components of the structure. Method: The research methodology employed in this study is based on a systematic review of relevant literature to investigate the use of CLT in tall buildings. The three selected aspects for this study will then be examined to gain in-depth knowledge of the challenges that arise. Interviews will be conducted regarding moisture and fire aspects to obtain firsthand insights from industry experts on how these challenges are addressed. The third component, concerning connections, will be investigated using literature on various types of connections used in CLT buildings. Two different solutions will be evaluated and compared based on observations and documentation from sitevisits. Results: CLT is a building material that exhibits certain challenges regarding connections, fire resistance, and moisture. This study investigated various solutions to address these three aspects. Moisture control can be achieved through different measures such as weather protection, moisture measurements, and on-site or pre-manufacturing drying of CLT. Fire solutions commonly employed include fire-retardant coatings, sprinklersystems, and fire-resistant gypsum boards. Another viable approach is oversizing, taking advantage of wood's natural charring process. The two most common connection solutions for the selected joints are angle brackets and long timber screws. These solutions yield comparable results in terms of load-bearing capacities but require distinct approaches to installation and fireinsulation. Conclusions: This study investigated challenges related to three aspects in order to develop effective solutions for these various challenges. The solutions examined in this work are viable and applicable, but careful consideration must be given to their practical implementation. All three aspects require meticulous planning and expertise, and the application should also be carried out correctly.