Mobile Health (mHealth) in evidence-based patient care is a fast-growing technology that is yet to be adapted in the healthcare setting for managing asthma. This research thesis aims to understand the determinant factors that can be recognized as drivers and barriers for mHealth implementation for asthma.  The literature review chapter outlined the aspects of wicked problems in implementing innovation, and the study of implementation science explained in relevant to the implementation of mHealth in the healthcare system. The selected framework is based on the implementation outcome and addressed all four categories of human organizational levels. A qualitative case study was carried out in metropolitan cities of India, and a purposive sampling method is applied to choose the engaged pulmonologist & healthcare providers.  The empirical findings are categorized into themes using thematic analysis and identified the barriers and drivers under five themes, such as Technology, Human Factor, System, Literacy and Process.  The aspects under the theme technology include integrating IoT systems and data platforms, pre-testing, and adaptability. In contrast, the human factor’s theme revolves around the patient behaviour and attitude, emotions and beliefs on the technology. The aspects under the system and literacy theme mainly suggest that health literacy and language play a significant role. The results of these empirical studies have not previously been explored in the literature. And finally, the process theme indicates that the doctors play an essential role as an opinion leader and implementation leader in driving the implementation efforts. The analysis concludes that the determinant factors acting as barrier and driver are more under the human factors, technology and system aspects. These factors need to be considered when implementing the mHealth intervention for asthma management, and the role of healthcare practitioners engaging in the implementation process is foreseen as a potential driving factor for the successful outcome and technology acceptance by the patients.