Background.Studies have shown that low-grade chronic inflammation affect muscle mass negatively. Theimpact of inflammation in grip strength is not yet investigated. Existing studies are made on a few populations.This study aims to describe how inflammation, grip strength and muscle mass looks in agroup of 52-year-old men and women and to examine the differences between the sexes.Another aim is to investigate the correlations between low-grade chronic inflammation (n =32) and muscle mass (n = 23) and grip strength (n = 30).Method Data from an ongoing study were analyzed with a non-experimental descriptive, comparativeand correlating design. Lean muscle mass was calculated by subtracting the percentage of fatfrom weight. Grip strength was measured by Jamar dynamometer. CRP as inflammationparameter through blood-samples. Results The populations measured levels was consistent with current reference values för healthyindividuals. Tendencies to positive correlation between CRP and muscle mass could be seenfor both men and women. For men there were tendency towards positive correlation betweenCRP levels and grip strength, while tendency to negative correlation for women. Women hadhigher CRP levels compared to men. Men had higher levels of muscle mass and grip strength. Conclusion No conclusions could be drawn regarding the effect of low-grade chronic inflammation effectin fat-free mass and grip strength. The study has highlighted the need for further research inthe field.