Proton magnetic resonance has been measured in the temperature range -196° to 295°C for potassium caprylate, from -196° to 230°C for lithium stearate, and at -196° and 27°C for potassium caproate. Theoretical second moments for potassium caproate, caprylate and caprate at -196°C were computed using various molecular parameters and were compared with experimental values. Unfortunately the theoretical values were sufficiently alike for any one soap so that it could not be decided which of the parameters were applicable. The results do show, however, that the end methyl group rotates in potassium caproate at -196°C and probably does so in potassium caprylate and caprate. A sharp decrease in line width and second moment takes place in potassium caprylate between 50° and 55°C and between 283° and 286°C. The first transition corresponds to a known crystal phase change at 55°C. The second moment results suggest that some torsional oscillation about the longitudinal axes of the hydrocarbon chain portion of the potassium caprylate molecules takes place below 50° C. Above 55°C torsional oscillation of large amplitude or possibly even rotation of the hydrocarbon chain occurs. The transition between 283° and 286°C corresponds to onset of motion in the hydrocarbon chain restricted only by continued ordering of the polar end groups in the ionic layer of the soap. The proton magnetic resonance results in lithium stearate indicate transitions at 115°, 171+°, and 225°C. These pmr transitions correspond to known phase transitions. The second moment results suggest that the methyl group of the hydrocarbon chain in lithium stearate begins to rotate between-183° and -136°C. The second moment above 115°C is approximately equivalent to that estimated for rotation of the hydrocarbon chain about its long axis. Above 171°C very extensive motion of the chains occurs, although they are still held in position by the ionic layer. The ionic layer begins to break up in the region 215° to 218°C, with the compound becoming an isotropic liquid at about 225°C. / Science, Faculty of / Chemistry, Department of / Graduate

The management of acute myocardial infarction (AMI) has been improved by the realisation that the size of infarction can influence mortality (Sobel et al, 1972) and that the infarct size can be altered by subsequent therapy (Maroko et al, 1972). The identification of any factor which may have adverse effects on the ischaemic myocardium and which is amenable to treatment would therefore have important prognostic implications. Elevation of circulating free fatty acid (FFA) concentrations is a consistent feature (Kurien and Oliver, 1966; Oliver et al, 1968) of the profound, non-specific metabolic reaction associated with the onset of AMI (Opie, 1975). The FFA rise has been correlated with the development of arrhythmias (Oliver et al, 1968) after AMI, and with the severity of ischaemic damage (Oliver et al, 1968; Gupta et al, 1969; Russell & Oliver, 1978) on clinical grounds. The method of quantifying infarct size developed by Shell et al (1972) has provided a means of correlating the degree of metabolic disturbance with extent of myocardial damage, and of assessing the benefits of metabolic interventions. The purpose of the studies reported in this thesis was to examine in detail the FFA rise in the early phase of AMI and to correlate this rise with the development of arrhythmias and other complications of AMI and with enzymatically estimated infarct size, thus leading to a more rational approach to therapeutic interventions.

Fatty acid composition of five dwarf mistletoe species was analysed by Gas Liquid Chromatography. Because of the limitations of available equipment, only aerial shoots were analysed. Palmitic, oleic, linoleic and arachidic acids were the major components of total lipids. The sum of these acids accounted for 85-95 percent of total lipids present in the tissue. There was no apparent difference between species. The ratio of saturated acids to unsaturated acids in summer collections was higher than that of fall collections. Temperature may play an important role in controlling of these ratios. Lipid content varied from 3.25% to 8.5% on a dry weight basis depending on species.

This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).

This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).

The objectives of this study were to determine fatty acid composition and acrosome status from bull sperm with different freezabilities (n = 12). We hypothesized that lipid fractions had differentiated fatty acid compositions and such differences influence sperm freezability and the sperm acrosome. Fatty acids were extracted from fresh frozen sperm and fractionated by solid-phase extraction. Thirtyour fatty acids were quantified. Saturated fatty acids were predominant, accounting for 71 to 80% of fatty acids in both fractions. Differences in composition between fractions existed (P < 0.001). Branched chain fatty acid concentrations (15 to 18 µg) were almost twice that of polyunsaturated fatty acid concentrations found in the polar fractions (8 to 9 µg; P < 0.001). Sperm with differentiated freezabilities had few differences in 22:0, 18:1 cis 9, and 14:0 13-methyl fatty acids (P ≤ 0.011). Analyses of acrosome status of sperm revealed that acrosomes were affected differently among bulls.

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