The objective of this dissertation is to demonstrate the use of in situ TEM mechanical testing to find mechanical properties of as received, self-ion, and proton irradiated Fe-9%Cr ODS. The desire to work at small scale in the characterization of irradiated materials to reduce costs and improve throughput, require the development of novel methods to assess mechanical properties in volume-limited irradiation damage layers. Yet at these micrometer or nanometer scales, the mechanical properties can begin to be impacted by size effects. In this work micropillar compression, cantilever bending, lamellae indentation, and clamped beam fracture testing is conducted on ion-irradiated Fe-9%Cr ODS to find yield stress, elastic modulus, flow stress, and fracture toughness. Micropillars in compression allow us to define a minimum sample dimension, which approaches the obstacle spacing of the material, at which size effects are observed. This relationship between sample dimension and obstacle spacing defined through micropillar compression is extended to a new testing geometry, cantilever bending, and material property, flow stress. Lessons learned during the cantilever bending informed the clamped beam design for conducting fracture testing on a ductile engineering alloy at micrometer scales. Finally, lamellae indentation was conducted to link qualitative observations of the microstructure under load with literature strength of obstacle values. By combining an understanding of the microstructure of irradiated Fe-9%Cr ODS and the in situ TEM technique, one can find the bulk-like mechanical properties of ion irradiated Fe-9%Cr ODS.