1 |
Negative regulation of PGC-1α by NF-κBBlant, Alexandra 10 January 2014 (has links)
The normal adult heart prefers fatty acids as an energy substrate. In the case of heart
failure, the heart switches its preference from fatty acids to glucose, adopting a pattern
similar to fetal metabolism. PGC-1α is heavily involved in the shift towards glucose oxidation. p65, which belongs to the NF-κB transcription factor family is another crucial molecule involved in maintaining cardiac homeostasis. There is a substantial amount of evidence suggesting that PGC-1α and NF-κB directly interact,
thereby connecting metabolic and inflammatory processes. Dysregulation of
either PGC-1α or NF-κB signalling correlates to many diseases including heart disease.
In this study, we provide further evidence that the NF-κB family has the ability to repress
PGC-1α. We also show that the PGC-1α promoter contains a p65 binding site through
which p65 imparts control on the PGC-1α gene. Metabolic homeostasis and inflammation
pathways are closely linked and play crucial roles in heart dysfunction.
|
Page generated in 0.066 seconds