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Digital tomosynthesis is a novel three-dimensional imaging technology that utilizes limited number of X-ray projection images to improve the diagnosis and detection of lesions. In recent years, tomosynthesis has been used in a variety of clinical applications such as dental imaging, angiography, chest imaging, bone imaging, and breast imaging. The goal of our research is to develop a framework to enable flexible optimization and comparison of image reconstruction and imaging configurations.

Bladder artifacts during bone single photon emission computed tomography (SPECT) is a common source of errors. The extent and severity of bladder artifacts have been described for filtered back projection (FBP) reconstruction. OSEM may help to address this poor record of bladder artifacts, which render up to 20% of the images unreadable. Aims and objectives To evaluate the relationship of the bladder to acetabulum ratio in guiding the choice of the number of iterations and subsets used for OSEM reconstruction, for reducing bladder artifacts found on FBP reconstruction. Materials and Methods 105 patients with various indications for bone scans were selected and planar and SPECT images were acquired. The SPECT images were reconstructed with both filtered back projection and OSEM using four different combinations of iterations and subsets. The images were given to three well experienced Nuclear Physicians who were blinded to the diagnosis and type of reconstruction used. They then labelled images from the best to the worst after which the data was analysed. The bladder to acetabulum ratio for each image was determined which was then correlated with the different iterations and subsets used. Results The study demonstrated that reconstruction using OSEM led to better lesion detectability compared to filtered back projection in 87.62% of cases. It further demonstrated that the iterations and subsets used for reconstruction of an image correlates to the bladder to acetabulum ratio. Four iterations and 8 subsets yielded the best results in 48.5% of the images whilst two iterations and 8 subsets yielded the best results in 33.8%. The number of reconstructed images which yielded the best results with 2 iterations and 8 subsets were the same as or more than those with 4 iterations and 8 subsets when the bladder/acetabulum ratio was between 0.2-0.39. A ratio below 0.2 or above 0.39 supports the usage of 4 iterations and 8 subsets over 2 iterations and 8 subsets. Conclusion Bladder to acetabulum ratio can be used to select the optimum number of iterations and subsets for reconstruction of bone SPECT for accurate characterization of lesions. This study also confirms that reconstruction with OSEM (vs FBP) leads to better lesion detectability and characterisation. / Dissertation (MSc)--University of Pretoria, 2011. / Nuclear Medicine / unrestricted

This work addresses the application of non-premixed filtered tabulated chemistry as a turbulent combustion modeling strategy in the LES framework. On the first part of this study the effects of the filtering operation on non-premixed flamelets are carefully appraised, considering an individual flamelet and the entire manifold. Subsequently, a systematic approach is followed where first the numerical implementation is verified. Afterwards validation is done on a coflow laminar diffusion flame, where promising results encourage the further model appraisal on a more complex turbulent configuration. This is finally achieved under turbulent conditions of Flames D and E, where the formalism including a SGS wrinkling modeling function adequately describes the wrinkled flame front features. The formalism assessment on a laminar coflow diffusion flame reveals a considerable sensitivity to the flame dimensionality. A flame sensor based on the mixture fraction gradient, with a tolerance to take into account the numerical grid resolution, is introduced and proves to deliver satisfactory results. The sensor-determined model activation allows to adequately represent the underlying physics behind flame filtering and so it endorses the consistency of the numerical procedure. The evaluation of the non-premixed FTACLES model on turbulent flames D and E demonstrates that the formalism coupling with a SGS wrinkling modeling function can adequately describe the wrinkled flame front condition. The model performs significantly well employing a three-dimensional tabulation strategy, where the numerical grid is coupled with the model by the third parameter, i.e. the computational cell size. The predictions for both the major stable species and the minor ones accurately correspond with the undergoing physics. The obtained results have a deep theoretical implication for the combustion research. First, they confirm the idea that SGS closure in diffusive combustion can be derived based on filtering arguments, and not only based on statistical approaches. Second, they demonstrate the enormous potential of the non-premixed FTACLES formalism once a sound flame sensor and a SGS wrinkling modeling function are included. / Doctorat en Sciences de l'ingénieur et technologie / info:eu-repo/semantics/nonPublished

In a nuclear power plant, the last barrier under normal and accident operations is the containment building. This is normally constructed from concrete reinforced with steel bars, which are prestressed to enhance the overall capability to withstand thermodynamic stresses like over-pressurisation and high temperatures. The failure of this final barrier will lead to the release of radioactivity to the surrounding environment. To examine the effects of thermo-hydraulic stresses on PWR containment following a LOCA, a model is proposed with simulated scenarios performed at the Koeberg Nuclear Power Station as a case study. The accidents were simulated using the Koeberg engineering simulator to obtain the output data. The scenario for the proposed model correlates the critical mass flow from a double-ended guillotine break to the containment pressure and temperature increase. Different containment filtered venting systems (CFVS) are also investigated in this study as severe accident management systems. CFVS have historically been included in boiling water reactor (BWR) designs, but following the Fukushima Daiichi nuclear accident, they are being introduced as severe accident management systems to manage the threat of containment over-pressurisation in pressurised water reactors (PWR). Finally, the rate of change in containment pressure and temperature is analysed and compared to literature, with the incorporation of a simulated filtered venting system to the PWR containment building.

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We construct a strong filtered graph $\Gamma_s(\Lambda)$ dependent on the dominant weight $\Lambda$, and a weak filtered graph $\Gamma_w(\Kcen)$ dependent on the canonical central element $\Kcen$ for an arbitrary Kac-Moody algebra $g$. In our construction, both graphs $(\Gamma_s(\Lambda), \Gamma_w(\Kcen))$ have the vertex set as the Weyl group of $g$, with the grading given by the length function. The edges of the graph $\Gamma_s(\La)$ are labeled versions of the $\lambda$-chain model of K-Chevalley rules for Kac-Moody flag manifolds as developed by Lenart and Shimozono, originally defined by Lenart and Postnikov. Meanwhile, the labels on $\Gamma_w(\Kcen)$ come from the dual multiplication map of K-cohomology of affine Grassmannian $Gr_G$. We conjecture that the strong filtered graph and weak filtered graph are dual, which means we get an identity when we apply the up and down operators on the vertices. We proved this identity except one case that where we call the chain is $j$-present. Our identity is similar to the Möbius construction of the dual filtered graph, as previously studied by Patrias and Pylyavskyy, and in fact, in the limit $n\rightarrow \infty$ of the $A^{(1)}_{n-1}$, our construction recovers their identity. We also expect to recover their combinatorics of Möbius deformation of the shifted Young's lattice in type $C^{(1)}_n$ as $n$ approaches infinity. / Doctor of Philosophy / In this thesis, we introduce a pair of graphs $(\Gamma_s(\La),\Gamma_w(\Kcen))$ motivated by the study of affine Schubert calculus. Affine Schubert calculus emerges as an extension and generalization of classical Schubert calculus, which involves questions such as determining the number of lines intersecting four lines in three-dimensional space. This type of questions can often be translated into computations aimed at finding the structure constants for the Schubert basis in the K-(co)homology of the flag varieties such as affine Grassmannian. These structure constants represent the coefficients of the Schubert basis in the product of the other two Schubert bases, all indexed by the Weyl group of the affine Lie algebra $g$. We define up and down operators on the vertices of graphs $(\Gamma_s(\Lambda), \Gamma_w(\Kcen))$, which are elements in Weyl group of $g$, utilizing the structure constants as essential components. We conjecture that, in general, and prove in certain cases, this approach yields new identities for these operators, leading us to define this pair of graphs as a dual filtered graph.

Filtered Rayleigh scattering (FRS) is a non-intrusive, optical measurement technique that can currently provide time-averaged, simultaneous planar measurements of three-component velocity, static temperature, and static density of aerodynamic flows. Development of the FRS technique has typically employed 532 nm Nd:YAG lasers coupled with the use of iodine vapor cells as the molecular filter. One method to improve the effective signal-to-noise ratio (SNR), and therefore the performance of an FRS system, is to use shorter wavelengths. This takes advantage of the dependence of the Rayleigh scattering signal on the inverse of the wavelength of the incident laser light to the fourth power: even small shifts to shorter wavelengths can offer significant gains in SNR as a result. This study explores the implementation of an ultraviolet (UV) FRS system nominally at 387 nm with the use cesium vapor as the molecular filter. The cesium absorption lineshapes (corresponding to the 62S1/2 → 82P3/2 atomic transitions around 387 nm) are considered along with camera specifications to simulate an ultraviolet filtered Rayleigh scattering (UV FRS) measurement of aerodynamic flows. A signal model is developed using numerical functions for the cesium vapor cell transmission, camera specifications, signal-dependent shot noise, and signal-independent electronic detector read noise. Using this noise-inclusive model (over a 2.4 GHz scan bandwidth with a 7.5 cm long cesium vapor cell corresponding to current Virginia Tech FRS capabilities) velocity, static temperature, and static density measurement sensitivities for this proposed configuration are analyzed by evaluating and deriving the Cramér-Rao lower bound (CRLB) for each quantity. The effects of different flow conditions, Mie and geometric scattering levels, cesium vapor cell temperature, and spectral resolution are demonstrated. It is found that the best possible theoretical measurement results are obtained for high-speed wind tunnel flow conditions with high spectral resolution, and that the CRLB for velocity, static temperature, and static density for a 387 nm system approaches or exceeds that of a 532 nm system for a given signal-to-noise ratio (SNR). / Master of Science / One type of non-intrusive measurement technique that can be applied to aerodynamic flows is filtered Rayleigh scattering (FRS). Unlike other non-intrusive techniques such as particle image velocimetry (PIV) and Doppler global velocimetry (DGV), FRS does not require that the flow be seeded with particles and can provide simultaneous measurements of three-component velocity, static temperature, and static density. Current FRS measurement systems commonly use 532 nm green-light lasers and iodine cells for filtering. However, a stronger Rayleigh scattering signal (and therefore better measurement) can be attained by using shorter laser wavelengths as the strength of the Rayleigh scattering is related to the inverse of the incident wavelength to the fourth power. This study takes advantage of this fact to propose an FRS measurement system using ultraviolet laser light at nominally 387 nm. The implementation of a commercially available 387 nm laser system with the use of cesium cells for filtering is investigated. In order to simulate the performance of the system, a signal model is developed that includes both signal-dependent shot noise, and signal-independent electronic detector read noise. The signal model is combined with the transmission profile of cesium vapor, commercially available camera specifications, and typical FRS measurement parameters to simulate a 387 nm FRS system measurement. The measurement sensitives and performance of the proposed UV FRS system at 387 nm are investigated by deriving and evaluating the Cramér-Rao lower bound (CRLB) for velocity, static temperature, and static density. The effects of different flow conditions, Mie and geometric scattering levels, cesium vapor cell temperature, and scan resolution are demonstrated. The best performance is attained at high-speed conditions with high spectral resolution, and this approaches or exceeds the simulated performance of a 532 nm system with an iodine vapor cell over the same range of conditions.

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