With the increasing demand on wireless and portable devices, the radio frequency front end blocks are required to feature properties such as wideband, high frequency, multiple operating frequencies, low cost and compact size. However, the current radio frequency system blocks are designed by combining several individual frequency band blocks into one functional block, which increase the cost and size of devices. To address these issues, it is important to develop novel approaches to further advance the current design methodologies in both space and spectrum domains. In recent years, the concept of artificial materials has been proposed and studied intensively in RF/Microwave, Terahertz, and optical frequency range. It is a combination of conventional materials such as air, wood, metal and plastic. It can achieve the material properties that have not been found in nature. Therefore, the artificial material (i.e. meta-materials) provides design freedoms to control both the spectrum performance and geometrical structures of radio frequency front end blocks and other high frequency systems. In this dissertation, several artificial materials are proposed and designed by different methods, and their applications to different high frequency components and circuits are studied. First, quasi-conformal mapping (QCM) method is applied to design plasmonic wave-adapters and couplers working at the optical frequency range. Second, inverse QCM method is proposed to implement flattened Luneburg lens antennas and parabolic antennas in the microwave range. Third, a dual-band compact directional coupler is realized by applying artificial transmission lines. In addition, a fully symmetrical coupler with artificial lumped element structure is also implemented. Finally, a tunable on-chip inductor, compact CMOS transmission lines, and metamaterial-based interconnects are proposed using artificial metal structures. All the proposed designs are simulated in full-wave 3D electromagnetic solvers, and the measurement results agree well with the simulation results. These artificial material-based novel design methodologies pave the way toward next generation high frequency circuit, component, and system design.