Marburg, University, Diss., 2004. / Erscheinungsjahr an der Haupttitelstelle: 2003.

Zugl.: Köln, Universiẗat, Diss., 2004.

Berlin, Humboldt-University, Diss., 2000.

Thesis (Ph. D.)--Auburn University. / Abstract. Vita. Includes bibliographical references (p. 179-187).

Thesis (M.S.)--Ohio University, June, 1995. / Title from PDF t.p.

It has recently been shown that the binding site of SAHase, an enzyme critical in the replication mechanism of viruses, is quite flexible and exhibits a large difference between the "open" and "closed" conformations, thus presenting an obstacle towards design efforts. As a possible solution to this dilemma, we have strategically designed and synthesized a series of structurally innovative nucleosides possessing a heteroaromatic purine ring split into its two components (for example, an imidazole and pyrimidine ring), thereby conferring additional degrees of conformational freedom and torsional flexibility to the ligand. As a result, these molecular "chameleons" can adapt to the environment of the flexible binding site in order to maximize and complement structural interactions, without losing the integrity of the crucial contacts involved in the enzyme's mechanism of action. The synthesis of several proximal analogues is presented herein.

Thesis(M.S.)--Auburn University, 2005. / Abstract. Includes bibliographic references (p.129-134).

Thesis--Auburn University, 2009. / Abstract. Vita. Includes bibliographical references (p. 148-153).

Thesis (M.E.T.)--University of Canterbury, 2006. / Typescript (photocopy). Includes bibliographical references (p. 110-111). Also available via the World Wide Web.

Over the last few years, flexible electronic systems have gained increased attention from researchers around the world because of their potential to create new applications such as flexible displays, flexible energy harvesters, artificial skin, and health monitoring systems that cannot be integrated with conventional wafer based complementary metal oxide semiconductor processes. Most of the current efforts to create flexible high performance devices are based on the use of organic semiconductors. However, inherent material's limitations make them unsuitable for big data processing and high speed communications. The objective of my doctoral dissertation is to develop integration processes that allow the transformation of rigid high performance electronics into flexible ones while maintaining their performance and cost. In this work, two different techniques to transform inorganic complementary metal-oxide-semiconductor electronics into flexible ones have been developed using industry compatible processes. Furthermore, these techniques were used to realize flexible discrete devices and circuits which include metal-oxide-semiconductor field-effect-transistors, the first demonstration of flexible Fin-field-effect-transistors, and metal-oxide-semiconductors-based circuits. Finally, this thesis presents a new technique to package, integrate, and interconnect flexible high performance electronics using low cost additive manufacturing techniques such as 3D printing and inkjet printing. This thesis contains in depth studies on electrical, mechanical, and thermal properties of the fabricated devices.