Profile strips have been used in various industries and now the demand of profile strip is still growing. Due to different reductions at different parts of the strips, profile strips after rolling generate a defect which looks like a wave. This study will design and manufacture a four-high profile rolling mill, which can roll profile strips. Experiments and finite element simulation are conducted to discuss the effects of different parameters on strip size and the defect of the profiled strips. In this study, a finite element analysis software is used to establish profile rolling models with different material setting mode, reduction, temperature, material, tension, and roll shape. From the simulation results, the effects of these parameters on the defects are discussed. Secondly, profiled rolls are designed and a heating equipment is added on the four-high rolling mill, and rolling experiments with different reduction, materials, passes of process, roll shape and temperature are conducted. From the experimental results the effects of these parameters on size of the defect of profile strip are discussed. Finally, from the comparisons between simulation results and experiment results, the feasibility of finite element models are verified.