Thesis (Ph.D.)--Australian National University, 2004. / "This CD contains the software (mostly written in Perl) used for comparative structure analysis reported in Chapter 4 (str_comp directory), and for the CTLD database system described in Chapter 2 (CTLD_DB directory)."

No description available.

No description available.

Background Promoters are key players in gene regulation. They receive signals from various sources (e.g. cell surface receptors) and control the level of transcription initiation, which largely determines gene expression. In vertebrates, transcription start sites and surrounding regulatory elements are often poorly defined. To support promoter analysis, we present CORG http://corg.molgen.mpg.de, a framework for studying upstream regions including untranslated exons (5' UTR). Description The automated annotation of promoter regions integrates information of two kinds. First, statistically significant cross-species conservation within upstream regions of orthologous genes is detected. Pairwise as well as multiple sequence comparisons are computed. Second, binding site descriptions (position-weight matrices) are employed to predict conserved regulatory elements with a novel approach. Assembled EST sequences and verified transcription start sites are incorporated to distinguish exonic from other sequences. As of now, we have included 5 species in our analysis pipeline (man, mouse, rat, fugu and zebrafish). We characterized promoter regions of 16,127 groups of orthologous genes. All data are presented in an intuitive way via our web site. Users are free to export data for single genes or access larger data sets via our DAS server http://tomcat.molgen.mpg.de:8080/das. The benefits of our framework are exemplarily shown in the context of phylogenetic profiling of transcription factor binding sites and detection of microRNAs close to transcription start sites of our gene set. Conclusion The CORG platform is a versatile tool to support analyses of gene regulation in vertebrate promoter regions. Applications for CORG cover a broad range from studying evolution of DNA binding sites and promoter constitution to the discovery of new regulatory sequence elements (e.g. microRNAs and binding sites).

Thèse numérisée par la Direction des bibliothèques de l'Université de Montréal.

Este trabalho tem como objetivo compreender os processos composicionais contidos no Op. 199, Les Guitares bien Tempérés, de Mario Castelnuovo-Tedesco (1895-1968). Este ciclo de 24 prelúdios e fugas é a maior obra original para duo de violões e, vindo de um compositor não-violonista, contextualizam-se, aqui, pontos importantes de sua formação, de seus intérpretes e de seu período. Algumas perguntas se destacam no percurso da pesquisa: quem foi este compositor? Quais foram os fatos mais marcantes de sua formação musical? Por que esta obra é tão importante para a formação de duo de violões? Qual é o perfil bibliográfico que se encontra para a produção deste trabalho? E, principalmente, como se pode descrever o estilo desta obra? Fundamentando-se em referenciais teórico-metodológicos (STEBLIN, 1982; LARUE, 1992; OTERO, 1999; entre outros), o trabalho parte dos sentidos tradicionais do Prelúdio e da Fuga e de como o compositor se relaciona com eles. Mostra como resultados da pesquisa os parâmetros musicais, que permeiam a obra como um todo (macroestrutura) e dialogam entre as partes (média e microestrutura), entrecruzando os elementos contribuintes (som, harmonia, melodia e ritmo) e outros desdobramentos (tonalidades, texturas, intensidades, harmonias, melodias, andamentos, expressões e afetos/humores). Desse modo, a pesquisa levou à compressão de diversos processos composicionais contidos na obra. / The aim of this work is to understand the compositional techniques employed by Mario Castelnuovo-Tedesco (1895-1968) in his Op. 199, Les Guitares bien Tempérés. This cycle of 24 Preludes and Fugues for two guitars is known as the largest original work for guitar duo and, coming from a non-guitarist composer, elucidates various aspects of his background and the performance of his works. Some of the most important questions addressed include: Who is Castelnuovo-Tedesco? What were the highlights of his musical training? Why is this work so important to the guitar duo ensemble? What kind of bibliographic references are available on this work? And, most importantly, how can the style of this work be described? This work in based on theoretical-methodological references (STEBLIN, 1982; LARUE, 1992; OTERO, 1999; among others), it begins with a discussion of the composer\'s approach to the traditional definitions of Prelude and Fugue. The results of this research highlight the musical guidelines that permeate the work both as a whole (macrostructure) and in parts (middle and microstructure), crossing contributing elements (sound, harmony, melody and rhythm), and other details (keys, textures, dynamics, harmonies, tempos, expressions and affections/humor). Thus, this research has led to the understanding of multiple compositional processes contained in the work.

Este trabalho tem como objetivo compreender os processos composicionais contidos no Op. 199, Les Guitares bien Tempérés, de Mario Castelnuovo-Tedesco (1895-1968). Este ciclo de 24 prelúdios e fugas é a maior obra original para duo de violões e, vindo de um compositor não-violonista, contextualizam-se, aqui, pontos importantes de sua formação, de seus intérpretes e de seu período. Algumas perguntas se destacam no percurso da pesquisa: quem foi este compositor? Quais foram os fatos mais marcantes de sua formação musical? Por que esta obra é tão importante para a formação de duo de violões? Qual é o perfil bibliográfico que se encontra para a produção deste trabalho? E, principalmente, como se pode descrever o estilo desta obra? Fundamentando-se em referenciais teórico-metodológicos (STEBLIN, 1982; LARUE, 1992; OTERO, 1999; entre outros), o trabalho parte dos sentidos tradicionais do Prelúdio e da Fuga e de como o compositor se relaciona com eles. Mostra como resultados da pesquisa os parâmetros musicais, que permeiam a obra como um todo (macroestrutura) e dialogam entre as partes (média e microestrutura), entrecruzando os elementos contribuintes (som, harmonia, melodia e ritmo) e outros desdobramentos (tonalidades, texturas, intensidades, harmonias, melodias, andamentos, expressões e afetos/humores). Desse modo, a pesquisa levou à compressão de diversos processos composicionais contidos na obra. / The aim of this work is to understand the compositional techniques employed by Mario Castelnuovo-Tedesco (1895-1968) in his Op. 199, Les Guitares bien Tempérés. This cycle of 24 Preludes and Fugues for two guitars is known as the largest original work for guitar duo and, coming from a non-guitarist composer, elucidates various aspects of his background and the performance of his works. Some of the most important questions addressed include: Who is Castelnuovo-Tedesco? What were the highlights of his musical training? Why is this work so important to the guitar duo ensemble? What kind of bibliographic references are available on this work? And, most importantly, how can the style of this work be described? This work in based on theoretical-methodological references (STEBLIN, 1982; LARUE, 1992; OTERO, 1999; among others), it begins with a discussion of the composer\'s approach to the traditional definitions of Prelude and Fugue. The results of this research highlight the musical guidelines that permeate the work both as a whole (macrostructure) and in parts (middle and microstructure), crossing contributing elements (sound, harmony, melody and rhythm), and other details (keys, textures, dynamics, harmonies, tempos, expressions and affections/humor). Thus, this research has led to the understanding of multiple compositional processes contained in the work.