Reinforced concrete block shear walls (RCBSWs) are used as seismic force resisting systems in low- and medium-rise buildings. However, attributed to their nonlinear behavior and composite material nature, accurate prediction of their seismic performance relying only on mechanics is challenging. This study introduces multi-gene genetic programming (MGGP)— a class of bio-inspired artificial intelligence, to uncover the complexity of RCBSW behaviors and develop simplified procedures for predicting the full backbone curve of flexure-dominated fully grouted RCBSWs under cyclic loading. A piecewise linear backbone curve was developed using five secant stiffness expressions associated with cracking, yielding, 80% ultimate, ultimate, and 20% strength degradation (i.e., post-peak stage) derived through controlled MGGP. Based on the experimental results of large-scale cyclically loaded RCBSWs, compiled from previously reported studies, a variable selection procedure was performed to identify the most influential variable subset governing wall behaviors. Utilizing individual wall results, the MGGP stiffness expressions were first trained and tested, and their accuracy was subsequently compared to that of existing models employing various statistical measures. In addition, the predictability of the developed backbone model was assessed at the system-level against experimental results of two two-story buildings available in the literature. The outcomes obtained from this study demonstrate the power of MGGP approach in addressing the complexity of the cyclic behavior of RCBSWs at both component- and system-level—offering an efficient prediction tool that can be adopted by relevant seismic design standards pertaining to RCBSW buildings. / Thesis / Master of Applied Science (MASc)