This study involved families of young children with autism spectrum disorders to examine the feasibility of implementing an adapted version of the school-based Prevent-Teach- Reinforce (PTR) model. This research included two families who developed and implemented the intervention for their children in collaboration with the researcher. The PTR manual was modified for use in a family context. The PTR intervention was tested using a multiple baseline design across routines. Procedural fidelity was assessed during training and coaching, as well as family implementation fidelity and social validity. To examine the potential efficacy of the adapted PTR intervention, the children’s target problem behavior and functionally equivalent alternative behavior were measured using video observation across experimental conditions including a generalization probe. Results indicated that the adapted PTR model is associated with reduction in child problem behavior and increases in alternative behavior. This study expanded the current research on the PTR model and extended its use to a novel setting and population so that a standardized model for positive behavior support implementation can be developed in the family context.