O estudo das formas do relevo terrestre teve um avanço expressivo com a utilização das modernas ferramentas de sensoriamento remoto. Na região Amazônica, devido à vasta cobertura de nuvens, bruma e fumaça, quase que o ano inteiro, de certa forma, ocasiona dificuldade para levantamento com sensores ópticos. As melhores imagens para a região, portanto, são as imagens provenientes de radar, pois esse sistema tem a vantagem de adquirir imagens, independente, da presença de nuvens ou fumaça. Desta forma, este trabalho teve por objetivo principal o uso das imagens do Radar de Abertura Sintética (SAR) R99B para o mapeamento geomorfológico ao longo do furo do Ariaú no município de Iranduba. A escolha desta área se justifica por apresentar características naturais e socioeconômicas bem peculiares. Na questão natural, Iranduba está encravado entre os dois maiores caudal da região: rio Negro e Solimões/Amazonas e composto de um ambiente de terra firme e várzea. Na questão socioeconômica, é nesse município que se encontra, também, o maior polo oleiro do estado do Amazonas. A metodologia empregada neste trabalho foi baseada na adaptação dos métodos propostos por Lima (1995), composta de três fases: identificação, análise e interpretação. O método proposto permitiu a interpretação das feições geomorfológicas baseadas na textura das imagens SAR/R99B com múltiplas polarizações para as terras baixas com altitude não ultrapassando 100 m. A fim de buscar entender a dinâmica fluvial da área do Ariaú foi realizado trabalho de campo e levantamento pedológico. Como resultado desta pesquisa, obteve-se mapa da drenagem, mapa geomorfológico das feições fluviais e os principais nutrientes do solo na calha do Ariaú. As imagens do SAR mostraram-se eficientes para as diferentes feições geomorfológicas para o mapeamento de média escala, no entanto, a falta de imagens nos diversos períodos hidrológicos, seca, enchente, cheia e vazante, de certa forma, compromete um melhor entendimento do ambiente. Este trabalho, portanto, coloca-se como uma perspectiva para novas interpretações geomorfológicas dos ambientes fluviais nas áreas baixas da Amazônia. / The study of the forms of terrestrial landscape had a significant progress with the use of modern remote sensing tools. In the Amazon region, due to extensive cloud cover, haze and smoke, almost the entire year, somehow, causes difficulty imaging with optical sensors. The best images for the region, are the pictures from Radar because this system has the advantage of acquiring images, independent of the presence of clouds or smoke. Thus, this work aimed to use pictures of the Synthetic Aperture Radar (SAR) R99B for geomorphological mapping along the Furo do Ariaú in the municipality of Iranduba. The choice of this area is justified due to its peculiar natural and socioeconomic characteristics. In the natural matter, Iranduba is wedged between the two major flow region: Rio Negro and Solimões /Amazonas and composed of an environment of upland and floodplain. In the socioeconomic issue, it is in this city that lays the largest polo potter in the state of Amazonas. The methodology used in this study was based on the adaptation of the methods proposed by Lima (1995), composed of three phases: identification, analysis and interpretation. The proposed method allowed the interpretation of geomorphological features based on texture of SAR/R99B images with multiple polarizations to the lowlands to an altitude not exceeding 100m. In order to try to understand the dynamics of the Ariaú river area fieldwork and soil survey were conducted. As a result of this research a map was obtained, including the drainage map, geomorphological map of the river and the main nutrients in the soil trough Ariaú. The SAR images were effective for different geomorphological mapping to medium scale, however, the lack of pictures in different hydrological periods, drought, flooding and receding somewhat, compromises a better understanding of the environment. This work, therefore, arises as a prospect for new interpretations of fluvial geomorphic low-lying areas of the Amazon.

O estudo das formas do relevo terrestre teve um avanço expressivo com a utilização das modernas ferramentas de sensoriamento remoto. Na região Amazônica, devido à vasta cobertura de nuvens, bruma e fumaça, quase que o ano inteiro, de certa forma, ocasiona dificuldade para levantamento com sensores ópticos. As melhores imagens para a região, portanto, são as imagens provenientes de radar, pois esse sistema tem a vantagem de adquirir imagens, independente, da presença de nuvens ou fumaça. Desta forma, este trabalho teve por objetivo principal o uso das imagens do Radar de Abertura Sintética (SAR) R99B para o mapeamento geomorfológico ao longo do furo do Ariaú no município de Iranduba. A escolha desta área se justifica por apresentar características naturais e socioeconômicas bem peculiares. Na questão natural, Iranduba está encravado entre os dois maiores caudal da região: rio Negro e Solimões/Amazonas e composto de um ambiente de terra firme e várzea. Na questão socioeconômica, é nesse município que se encontra, também, o maior polo oleiro do estado do Amazonas. A metodologia empregada neste trabalho foi baseada na adaptação dos métodos propostos por Lima (1995), composta de três fases: identificação, análise e interpretação. O método proposto permitiu a interpretação das feições geomorfológicas baseadas na textura das imagens SAR/R99B com múltiplas polarizações para as terras baixas com altitude não ultrapassando 100 m. A fim de buscar entender a dinâmica fluvial da área do Ariaú foi realizado trabalho de campo e levantamento pedológico. Como resultado desta pesquisa, obteve-se mapa da drenagem, mapa geomorfológico das feições fluviais e os principais nutrientes do solo na calha do Ariaú. As imagens do SAR mostraram-se eficientes para as diferentes feições geomorfológicas para o mapeamento de média escala, no entanto, a falta de imagens nos diversos períodos hidrológicos, seca, enchente, cheia e vazante, de certa forma, compromete um melhor entendimento do ambiente. Este trabalho, portanto, coloca-se como uma perspectiva para novas interpretações geomorfológicas dos ambientes fluviais nas áreas baixas da Amazônia. / The study of the forms of terrestrial landscape had a significant progress with the use of modern remote sensing tools. In the Amazon region, due to extensive cloud cover, haze and smoke, almost the entire year, somehow, causes difficulty imaging with optical sensors. The best images for the region, are the pictures from Radar because this system has the advantage of acquiring images, independent of the presence of clouds or smoke. Thus, this work aimed to use pictures of the Synthetic Aperture Radar (SAR) R99B for geomorphological mapping along the Furo do Ariaú in the municipality of Iranduba. The choice of this area is justified due to its peculiar natural and socioeconomic characteristics. In the natural matter, Iranduba is wedged between the two major flow region: Rio Negro and Solimões /Amazonas and composed of an environment of upland and floodplain. In the socioeconomic issue, it is in this city that lays the largest polo potter in the state of Amazonas. The methodology used in this study was based on the adaptation of the methods proposed by Lima (1995), composed of three phases: identification, analysis and interpretation. The proposed method allowed the interpretation of geomorphological features based on texture of SAR/R99B images with multiple polarizations to the lowlands to an altitude not exceeding 100m. In order to try to understand the dynamics of the Ariaú river area fieldwork and soil survey were conducted. As a result of this research a map was obtained, including the drainage map, geomorphological map of the river and the main nutrients in the soil trough Ariaú. The SAR images were effective for different geomorphological mapping to medium scale, however, the lack of pictures in different hydrological periods, drought, flooding and receding somewhat, compromises a better understanding of the environment. This work, therefore, arises as a prospect for new interpretations of fluvial geomorphic low-lying areas of the Amazon.

Ferrets are labelled Unwanted Organisms under the Biosecurity Act (1993) due to their predation on New Zealand's native protected species and their status as potential vectors of Bovine Tuberculosis. There was suspicion that ferrets could detect the infrared light-emitting equipment used to monitor predator and prey behaviour. A two-alternative forced-choice operant procedure was used to test whether five pigmented male ferrets could detect infrared (870 and 920 nm) light. First, the ferrets were taught to press a lever under a lit visible (white) light emitting diode (LED) for food rewards. After up to 101 40-minute sessions, each ferret could lever press under the lit-light at or above the pass criteria of 75% responses over four consecutive (or five out of six) sessions. The same ferrets were then tested for stimulus generalisation over different stimulus properties by changing the wavelength/colour and intensity of the lit-light. The overall mean accuracy of each ferret's response to each coloured light varied between 92% and 84%. When a red light was systematically dimmed to halve the intensity nine times, all five ferrets still met the set pass criteria with overall accuracies of between 88% and 78%. This indicated that changing the properties of the light stimuli would not disrupt the ferrets' abilities to perform the learned task. This test was a necessary prerequisite before changing the light stimuli to potentially invisible wavelengths in the infrared spectrum. The light stimulus was changed to a single infrared (870) nm LED. Two of five ferrets showed strong evidence (response accuracies of 77% 4 and 72% 2) and one ferret showed weak evidence (60% 3) that they could see the light at this wavelength. Extraneous cues such as ultrasound emitted at the onset of a stimulus light or a predictable schedule of reinforcement were eliminated as potential response cues. These tests helped to prove that the ferrets were using only the light stimulus to discriminate which stimulus was lit. It may be possible that at least some feral ferrets can detect the light produced from infrared monitoring equipment that emits light wavelengths at or below 870 nm. This has significant implications for conservation because infrared equipment is used by conservation agencies in New Zealand and overseas to monitor predator and prey behaviour in the wild. If the infrared lighting is detected by the subject being observed, then it may potentially influence the behaviour of the animal, or attract a predator towards threatened native species.

La mélatonine est une neurohormone sécrétée en période nocturne dans la glande pinéale. Elle régule les rythmes biologiques et influe sur différents processus physiologiques. Son implication ainsi que celle de la sérotonine, un neurotransmetteur, dans certains troubles de l’humeur font des récepteurs associés à ces deux hormones (MT1, MT2 et 5-HT2C respectivement) des cibles innovantes pour le développement de nouveaux antidépresseurs. Dans le cadre de cette thèse, des ligands mixtes mélatoninergiques et sérotoninergiques en série 7-azaindolique ont été synthétisés et testés biologiquement. L’élaboration de dérivés furo[3,2-b]pyridiniques a permis d’évaluer le potentiel biologique de ce squelette original et de mettre au point une nouvelle méthode de synthèse de ce motif. Ces travaux ont également été l’occasion d’étudier l’influence sur l’affinité et l’activité mélatoninergiques de la présence de différents groupements aryles plus ou moins volumineux en position 2 du noyau. Le dernier objectif a consisté dans le développement d’une voie d’accès à des analogues furopyridiniques tricycliques. Le raisonnement méthodologique poursuivi réside dans la mise en place d’une séquence réactionnelle permettant d’accéder aux structures désirées via une procédure courte et efficace. / Melatonin is a neurohormone secreted in the pineal gland during dark phases. This regulator of the biological clock is thus involved in several physiological process. Melatonin and serotonin, a neurotransmitter, are involved in some mood disorders, leading to consider associated receptors (MT1, MT2 and 5-HT2C respectively) as innovative targets for the development of new antidepressant.During this PhD, some 7-azaindolic ligands with both melatoninergic and serotoninergic activity were synthesized and tested from a biological point of view.Elaboration of furo[3,2-b]pyridinic derivatives allow us to evaluate the biological potential of this scaffold and to develop a new synthetic pathway to this pattern. This work has been the opportunity to study the influence of bulky aryl groups at C2 position over affinity and activity of these molecules towards melatoninergic receptors.The last aim consisted in developing a new methodology to access tricyclic furopyridinic analogues with a short and efficient chemical sequence.

[pt] O conhecimento dos esforços de flexão e normal provocados por movimentação de solo é importante para a análise de integridade estrutural de dutos. A existência de tensões residuais é um dos principais obstáculos para obtenção de resultados precisos na determinação de tais esforços. Este trabalho foi desenvolvido com o objetivo de analisar o comportamento das tensões residuais de fabricação em tubos ao longo de sua circunferência e de seu comprimento. Foram feitas medições de tensões residuais em corpos de prova de um tubo novo e de outros retirados de operação utilizando a técnica de furo cego e uma nova técnica de seccionamento. As medições foram realizadas ao longo da circunferência e em diferentes seções dos tubos. As medições com a técnica de seccionamento proposta, denominada técnica do furo elíptico, mostraram-se coerentes com as medições com o furo cego, principalmente para as tensões longitudinais. A partir dos resultados obtidos nos experimentos realizados, foram feitas recomendações e propostas metodologias para separar as tensões residuais de fabricação das tensões atuantes no duto em operação. Para cada método proposto foi feita uma simulação para avaliar seus erros. As tensões residuais de fabricação circunferenciais e longitudinais possuem magnitudes consideráveis (por vezes até próximas à resistência ao escoamento dos tubos). Desprezá-las em medições realizadas em campo, como é feito na maioria das vezes para calcular os esforços existentes, pode acarretar grandes erros na determinação dos esforços agindo sobre o duto. Os resultados das simulações mostraram que, se as tensões residuais forem baixas, os esforços de trabalho obtidos desconsiderando-as são próximos dos valores reais. No mais, os procedimentos propostos para a determinação dos esforços, mediante a separação das tensões residuais existentes, apresentaram erros menores ou, no mínimo, próximos aos encontrados quando o cálculo foi feito negligenciando-se as tensões residuais. / [en] The knowledge of the bending and axial efforts caused by soil movement is important for the structural integrity analysis of pipelines. The existence of residual stresses is one of the main obstacles for obtaining good results in the determination of such efforts. This work was developed to analyze the behavior of the residual stresses of manufacturing in pipes throughout its circumference and length. Measurements of residual stresses had been made in samples of a new pipe and others samplers removed from operation, using the hole drilling technique and a new sectioning technique. The measurements had been carried throughout the circumference and different sections of the pipes. The measurements with the sectioning technique proposed, called elliptical hole technique, are coherent with the measurements of the hole drilling technique, mainly for the longitudinal stresses. From the experimental results, recommendations had been made and methodologies had been proposed to separate the manufacturing residual stresses from the operating stresses in the pipelines. For each method considered in this work, a simulation was made to evaluate its errors. The circumferential and longitudinal residual stresses of manufacturing have considerable magnitudes (sometimes next to the yield strength of the pipes). Not considering the residual stresses in measurements carried through in situ to calculate the existing loads, as it is made most of the time, can cause significant errors in the determination of the efforts acting on the pipeline. The results of the simulations had shown that, if the residual stresses are low, the work loads obtained when the residual stresses are not considered are comparable with the correct loads. The procedures proposed for the determination of loads, considering the separation of the existing residual stresses, had presented smaller errors or closer to those when the calculation was made neglecting the residual stresses.

This dissertation describes an introduction, background and research progress in the areas of multitargeted single agents and tubulin inhibitors in cancer chemotherapy and selective Toxoplasma gondii TS inhibitors for the treatment of toxoplasmosis.<br> Tubulin inhibitors are important antitumor agents that disrupt microtubule dynamics. Thymidylate synthase (TS) inhibitors prevent cell division by interfering with de novo thymidylate synthesis. Antiangiogenic agents target tumor angiogenesis crucial for tumor growth and metastasis. Under normal circumstances, angiogenesis is typically limited to tumor cells and is mediated by receptor tyrosine kinases (RTKs). Combination chemotherapies of RTK inhibitors with cytotoxic agents that target either TS or tubulin have shown significant promise and several preclinical and clinical studies with such combinations are in progress. Multitargeted single agents with dual antiangiogenic and cytotoxic mechanisms could avoid the major limitations associated with cancer chemotherapy: multidrug resistance and dose limiting toxicities. This dissertation focuses on the design and synthesis of pyrimido[4,5-b]indoles and furo[2,3-d]pyrimidines as potential single agents with dual antiangiogenic and cytotoxic activities. These efforts led to the identification of structural features that are necessary for inhibition of RTKs and/or tubulin polymerization. Novel synthetic strategies were developed for efficient synthesis of 2,4-diamino-5-thioaryl-pyrimido[4,5-b]indoles and 4-anilino-5-methyl-furo[2,3-d]pyrimidines.<br> Taxanes and vinca alkaloids are widely used tubulin inhibitors in cancer chemotherapy. However, their clinical use is compromised by two major mechanisms of drug resistance: the overexpression of Pgp and bIII-tubulin. This dissertation describes the design and synthesis of pyrimido[4,5-b]indoles as tubulin inhibitors that circumvent Pgp and bIII-tubulin mediated resistance. This work identified the structural features crucial for tubulin inhibition for the pyrimido[4,5-b]indole scaffold.<br> Infection by Toxoplasma gondii can lead to toxoplasmosis in immune compromised patients such as organ transplant, cancer and AIDS patients. Current therapy involving combination of sulfadiazine and pyrimethamine is limited by drug resistance and treatment failures. The thymidylate synthase‒dihydrofolate reductase enzyme is important for thymidylate synthesis in T. gondii, and hence can be targeted to treat T. gondii infection. TS is highly conserved across species and selectivity for tgTS over human TS is significantly more challenging. The present work provides an efficient synthesis of 2-diamino-4-oxo-5-thioaryl-pyrimido[4,5-b]indoles as selective tgTS inhibitors. / Mylan School of Pharmacy and the Graduate School of Pharmaceutical Sciences; / Medicinal Chemistry / PhD; / Dissertation;

Le travail décrit dans ce mémoire concerne l'étude de la métallation régiosélective de deux bicycles fusionnés complexes : les furo[3,2-b]- et [2,3-c]pyridines. L'influence de la nature du système basique sur le cours de la réaction et sur la régiosélectivité de la lithiation a été étudiée avec différentes bases : n-BuLi, LTMP, LDA et [n-BuLi/LiDMAE]. D'un point de vue fondamental, cette étude nous a permis d'établir quelques règles pour la fonctionnalisation des hétérocycles complexes, ce qui nous a conduit à l'obtention efficace et rapide d'une vaste chimiothèque de furo[3,2-b]- et [2,3-c]pyridines polyfonctionnalisés et refonctionnalisables. Quelques composés préparés ont ainsi été mis en jeu dans des réactions de couplage catalysées par les métaux de transition (Pd, Ni). Les difficultés rencontrées au cours de ce travail nous ont permises de mettre en évidence une séquence de double fonctionnalisation des hétérocycles ?-déficients par une séquence "one-pot" combinant le piégeage d'un intermédiaire lithié par un électrophile et l'addition nucléophile d'une espèce réactive générée in-situ. Le développement de cette séquence nous a conduits à l'obtention directe de pyrazines, pyridines et furo[3,2-b]pyridines disubstituées / The work described in this PhD thesis concerns a regioselective metalation study of two fused heterocycles : the furo[3,2-b]- et [2,3-c]pyridines. The influence of the lithiated agent on the reaction course and on the selectivity of the lithiation has been studied with several bases : n-BuLi, LTMP, LDA and [n-BuLi/LiDMAE]. From a fundamental point of view, this study allowed us to establish some rules concerning the functionalisation of fused heterocycles, and then, a chemical library of polyfunctionalised furo[3,2-b]- and [2,3-c]pyridines has been designed. Some of the compounds obtained in this way were engaged in metallo-catalysed coupling reactions. The difficulties we met during this work allowed us to discover a double functionalisation sequence of ?-deficient heterocycles via a cascade process combining the trapping of lithiated intermediates and the nucleophilic addition of some in-situ released species. The development of this sequence afforded direct access to difunctionalised pyrazines, pyridines and furo[3,2-b]pyridines

This thesis is about making inference on the host status of feral ferrets in New Zealand for Mycobacterium bovis, the aetiological agent of bovine tuberculosis. The central question addressed is whether the rate of intra-specific transmission of M. bovis among ferrets is sufficient for the disease to persist in ferret populations in the absence of external, non-ferret sources of infection (inter-specific transmission). The question is tackled in three parts�firstly using model selection to identify suitable models for estimating the force of M. bovis infection in ferret populations; secondly applying statistical hypothesis testing to the results of planned manipulative field experiments to test the relationship between M. bovis infection in brushtail possums and that in ferrets; and thirdly using modelling to estimate intra-specific disease transmission rates and the basic reproductive rate (Ro) of M. bovis infection in ferrets. The model selection approach clearly identified the hypothesis of oral infection related to diet was, as modelled by a constant force of infection from the age of weaning, the best approximation of how M. bovis infection was transmitted to ferrets. No other form of transmission (e.g., during fighting, mating, or routine social interaction) was supported in comparison. The force of infection (λ) ranged from 0.14 yr-1 to 5.77 yr-1, and was significantly higher (2.2 times) in male than female ferrets. Statistical hypothesis testing revealed transmission of M. bovis to ferrets occurred from both brushtail possums and ferrets. The force of M. bovis infection in ferrets was reduced by 88% (λ=0.3 yr-1 vs. λ=2.5 yr-1) at sites with reductions in the population density of sympatric brushtail possum populations. A smaller decline in the force of infection resulting from the lethal cross-sectional sampling of the ferret populations was also demonstrated. The modelling approach estimated the basic reproductive rate (Ro) of M. bovis infection in ferrets in New Zealand to vary from 0.17 at the lowest population density (0.5 km-2) recorded to 1.6 at the highest population density (3.4 km-2) recorded. The estimates of Ro were moderately imprecise, with a coefficient of variation of 76%. Despite this imprecision, the Ro for M. bovis infection in ferrets was significantly less than unity for all North Island sites surveyed. Hence it is inferred ferrets are spillover hosts (0<Ro<1) for M. bovis infection in these environments. That is, M. bovis infection will progressively disappear from these ferret populations if the source of inter-specific transmission is eliminated. The estimates of Ro for M. bovis infection in South Island ferret populations were above one (the level required for disease establishment) for a number (5/10) of populations, though the imprecision made it impossible to ascertain whether Ro was significantly greater than one. The estimated threshold population density (Kt) for disease establishment was 2.9 ferrets km-2. It is inferred that, given sufficient population density (>Kt), the rate of intra-specific transmission of M. bovis among ferrets is sufficient for the disease to establish in ferrets in the absence of interspecific transmission. In these areas, ferrets would be considered maintenance hosts for the disease. Active management (e.g., density reduction or vaccination) of ferrets would be required to eradicate M. bovis from ferret populations in these areas, in addition to the elimination of sources of inter-specific transmission, particularly brushtail possums.

Submitted by Automação e Estatística (sst@bczm.ufrn.br) on 2018-04-11T20:54:52Z No. of bitstreams: 1 RaphaelSiqueiraFontes_TESE.pdf: 14059657 bytes, checksum: 1966f333453864809a63de0421cb1e86 (MD5) / Approved for entry into archive by Arlan Eloi Leite Silva (eloihistoriador@yahoo.com.br) on 2018-04-16T23:33:45Z (GMT) No. of bitstreams: 1 RaphaelSiqueiraFontes_TESE.pdf: 14059657 bytes, checksum: 1966f333453864809a63de0421cb1e86 (MD5) / Made available in DSpace on 2018-04-16T23:33:45Z (GMT). No. of bitstreams: 1 RaphaelSiqueiraFontes_TESE.pdf: 14059657 bytes, checksum: 1966f333453864809a63de0421cb1e86 (MD5) Previous issue date: 2017-12-14 / A proposta desta Tese de Doutorado é determinar a influência na resposta mecânica de laminados compósitos à base de tecidos multiaxiais acoplados de fibras de vidro-E e matriz epóxi éster vinílica, quando em presença de descontinuidade geométrica, aqui caracterizada por um furo circular. Nesse estudo do fenômeno da concentração de tensão é dado ênfase ao comportamento da deformação na vizinhança do furo, tendo em vista a característica do tecido de reforço ter suas camadas básicas acopladas através de fios de costura, tornando-os mais compactos em sua capacidade de suporte de carga. Esse estudo é desenvolvido a partir da medição das deformações na vizinhança do furo, utilizando a técnica de medição por Extensometria, frente aos ensaios de tração uniaxial. Por fim, serão apresentados os resultados em termos quantitativos sobre o efeito da presença da descontinuidade geométrica, mediante os cálculos da Resistência Residual (RS), do Módulo Residual (RM) e dos Fatores de Concentração de Tensão (K, calculados a partir de variados métodos analíticos), além da determinação das distribuições das deformações (obtidas das leituras dos extensômetros) na vizinhança do furo nos laminados em estudo, nas orientações 0°, 90° e 45° dos CPs. Essas distribuições são validadas utilizando a solução analítica proposta por Lekhnitskii (1968) e Konish e Whitney (1975), amplamente utilizada para materiais compósitos ortotrópicos. Ao ser efetuada a comparação entre os valores medidos experimentalmente e as distribuições analíticas das deformações, observou-se pouca interferência dos valores de K adotados para a obtenção das curvas analíticas, resultando numa concordância entre os valores obtidos pelos extensômetros e o modelo analítico. / The proposal of this Doctoral Thesis is to determine the influence on the mechanical response of composite laminates based on E-glass multiaxial Non-Crimp Fabrics and epoxy vinyl ester matrix, with the presence of geometric discontinuity, here characterized by a circular hole. In this study of the stress concentration phenomenon, emphasis is given to the strain behavior in the vicinity of the hole, since the reinforcing fabric characteristic, whose basic layers are coupled by stitching, making them more compact in their load support capacity. This study is developed from the strain measurement in the vicinity of the hole, using the technique of measurement by strain gages, during uniaxial tensile tests. Finally, the effect of the presence of the geometric discontinuity will be presented in quantitative terms, by means of the Residual Strength (RS), Residual Modulus (RM) and the Stress Concentration Factors (K, obtained by different analytical methods), in addition to the determination of strain distributions (obtained from strain gage measurements) in the vicinity of the hole in the laminates under study, in 0°, 90° and 45° orientations of the specimens. These distributions are validated using the analytical solution proposed by Lekhnitskii (1968) and Konish and Whitney (1975), widely used for orthotropic composite materials. When comparing the experimentally measured values with the analytical distributions of the strains, was observed little interference of the K values adopted to obtain the analytical curves, resulting in an agreement between the values obtained by the strain gages and the analytical model.

[pt] A determinação do fator teórico ou geométrico de concentração de tensões em um cilíndrico oco de paredes espessas com furo lateral oblíquo é o objeto deste estudo. É analisada a influência do ângulo de ineliação do furo lateral sobre o fator teórico de concentração de tensões. Foi usado na análise, o método fotoelástico. Os cilindros foram fabricados com uma mistura de araldite CY-205, anidrido ftálico e anidrido maleico. O carregamento é feito, introduzindo-se no cilindro um pino fabricado com o mesmo material. É usada a técnica do congelamento das tensões. Para determinar as tensões, o cilindro é cortado em fatias que são analisados em um polariscópio. São apresentadas conclusões, formuladas a partir dos resultados obtidos na experiência. Com este trabalho, novos dados são acrescidos ao problema de concentração de tensões, ampliando os recursos para aqueles que se dedicam ao projeto de máquinas. / [en] The study deals with the problem of concentration of stress introduced by the oblique hole in th thick wall cylinder. The influence of the angle of the axes of hole and cylinder in the stress concentration factor is studied by the method of three-dimensional photoelasticity. The cylinder was manufactured from the CIBA CY-205 epoxy resin cured by mixture of phtalic and maleic anhydrides, loaded by the inner pin and studied by the stress freezing method. The results are presented, which forms of dimensionless diagrams, which permits designer to calculate stresses using the simple Lame’s formula.