Dietary vitamin E, highly expressed in palm oil, exists as either tocopherols or tocotrienols. Evidence indicates that vitamin Es maybe potent cancer preventive agents. In this study, the y- and O- isoforms of vitamin E were found to he the most effective at cancer cell growth inhibition, with the tocotrienols being more effective than the tocopherols in androgen-independent PC-3 prostate cancer cells. To assure that these compounds were selective toward cancer cells, the growth arrest of PrEC normal prostate cells was compared to PC-3 cells. At concentrations of -30 iM dietary, y-vitamin Es showed no signficant growth arrest on PrEC cell growth, hut selectively inhibited growth in the PC-3 cancer cells. Moreover y-Tocotrienol demonstrated a greater potential to inhibit growth in cancer cells at these lower concentrations than did y-Tocopherol. Two independent pathways important in carcinogenesis were tested: PPAR y and NFicB. The PPAR y was up regulated by both dietary y-vitamin Es by the modulation of the endogenous ligand 15-S-HETE, while NFicB was only regulated by y-Tocotrienol. The modulation of NFicB was confirmed by the down regulation of the pro-Apoptotic proteins clAP, xIAP, and BcL-2 which potentiate apoptosis and are down stream effectors of NFicB.

No description available.

<p>Gamma ray spectroscopy has provided enormous amounts of information on the behaviour and structure of atomic nuclei [SHA88, BEA92, EBE08]. Most of the major discoveries in experimental nuclear physics over the last five decades are strongly associated with improvements in detector technologies. Inorganic scintilators led to the discovery in 1963 of the first excited states of a rotational band based on the ground state of 162Dy. Improvements in peak-to-background ratios and detector resolutions obtained with germanium led to the first evidence of backbending which is associated with a two quasi-particle excitation in 162Dy [SHA88]. More recently the development of composite and highly-segmented Ge detectors has significantly increased the performance and power of detection systems. The Clover detector is such a detector system and is in use at iThemba LABS. This study concerns the evaluation of the particle transport code MCNPX 2.5.0 as a tool to model complex composite detectors such as the Clover. Lanthanum silicate (LSO) and Lead tungstate (PbWO) are also evaluated as possible suppressor shield materials. It is shown that reasonable agreement between experiment and simulation is found when the experiment is accurately reproduced. However, when complex detection modes are implemented in the detector based on the number of elements that fire, MCNPX cannot be used to model the detector performance exactly. Differences between simulated and experimental results are found in suppressed add-back mode. It is proposed that the discrepancies are due to limitations in implementation of the pulse-height and special anti-coincidence tally in MCNPX. LSO and PbWO are compared to BGO as suppressor shield materials. It is found that LSO is not an ideal material for a suppression shield. PbWO is shown to give performance values similar to that of BGO. The back-plug is shown to have no effect on the Peak-to-Total ratio but is effective at reducing the background at lower energies.</p>

No description available.

No description available.

<p>Gamma ray spectroscopy has provided enormous amounts of information on the behaviour and structure of atomic nuclei [SHA88, BEA92, EBE08]. Most of the major discoveries in experimental nuclear physics over the last five decades are strongly associated with improvements in detector technologies. Inorganic scintilators led to the discovery in 1963 of the first excited states of a rotational band based on the ground state of 162Dy. Improvements in peak-to-background ratios and detector resolutions obtained with germanium led to the first evidence of backbending which is associated with a two quasi-particle excitation in 162Dy [SHA88]. More recently the development of composite and highly-segmented Ge detectors has significantly increased the performance and power of detection systems. The Clover detector is such a detector system and is in use at iThemba LABS. This study concerns the evaluation of the particle transport code MCNPX 2.5.0 as a tool to model complex composite detectors such as the Clover. Lanthanum silicate (LSO) and Lead tungstate (PbWO) are also evaluated as possible suppressor shield materials. It is shown that reasonable agreement between experiment and simulation is found when the experiment is accurately reproduced. However, when complex detection modes are implemented in the detector based on the number of elements that fire, MCNPX cannot be used to model the detector performance exactly. Differences between simulated and experimental results are found in suppressed add-back mode. It is proposed that the discrepancies are due to limitations in implementation of the pulse-height and special anti-coincidence tally in MCNPX. LSO and PbWO are compared to BGO as suppressor shield materials. It is found that LSO is not an ideal material for a suppression shield. PbWO is shown to give performance values similar to that of BGO. The back-plug is shown to have no effect on the Peak-to-Total ratio but is effective at reducing the background at lower energies.</p>

In this study variations in Ortec and Hamner equipment with different types of detectors were utilized in coincidence circuits to receive the smallest lifetime values of nuclear states. Results from Ge(Li)-NaI(Tl) detectors were compared to results received when NaI(Tl)-NaI(Tl) detectors were combined in a coincidence circuit.Four different isotopes were investigated. Samples of 22Na and 60Co were utilized as prompt sources. The lifetimes of the 0.81 MeV energy level of i33Ba and the 0.124 MeV energy level of 154Eu were studied. These lifetimes have been reported as being 6.3 nsec and 1.18 nsec respectively.The best value received for the 154Eu energy state was a slope measurement of 5.85 ± 3.15 nsec. The smallest value for the 133Ba energy state was a centroid shift measurement of 6.93 nsec.

Thesis (Ph. D.)--University of Wisconsin--Madison, 1970. / Typescript. Vita. Description based on print version record. Includes bibliographical references (leaves 155-158).

Thesis (Ph. D.)--University of Texas at Austin, 2007. / Vita. Includes bibliographical references.

Magister Scientiae - MSc / Gamma ray spectroscopy has provided enormous amounts of information on the behaviour and structure of atomic nuclei [SHA88, BEA92, EBE08]. Most of the major discoveries in experimental nuclear physics over the last five decades are strongly associated with improvements in detector technologies. Inorganic scintilators led to the discovery in 1963 of the first excited states of a rotational band based on the ground state of 162Dy. Improvements in peak-to-background ratios and detector resolutions obtained with germanium led to the first evidence of backbending which is associated with a two quasi-particle excitation in 162Dy [SHA88]. More recently the development of composite and highly-segmented Ge detectors has significantly increased the performance and power of detection systems. The Clover detector is such a detector system and is in use at iThemba LABS. This study concerns the evaluation of the particle transport code MCNPX 2.5.0 as a tool to model complex composite detectors such as the Clover. Lanthanum silicate (LSO) and Lead tungstate (PbWO) are also evaluated as possible suppressor shield materials. It is shown that reasonable agreement between experiment and simulation is found when the experiment is accurately reproduced. However, when complex detection modes are implemented in the detector based on the number of elements that fire, MCNPX cannot be used to model the detector performance exactly. Differences between simulated and experimental results are found in suppressed add-back mode. It is proposed that the discrepancies are due to limitations in implementation of the pulse-height and special anti-coincidence tally in MCNPX. LSO and PbWO are compared to BGO as suppressor shield materials. It is found that LSO is not an ideal material for a suppression shield. PbWO is shown to give performance values similar to that of BGO. The back-plug is shown to have no effect on the Peak-to-Total ratio but is effective at reducing the background at lower energies. / South Africa