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Elucidation of ganglioside binding domain in the B-subunit of cholera toxinTan, T. F. January 2000 (has links)
Thesis (M. Phil.)--University of Hong Kong, 2000. / Includes bibliographical references (leaves.
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Elucidation of the sequence of the autophosphorylation site of ganglioside-stimulated protein kinaseWai, Chun-leung., 韋俊樑. January 2001 (has links)
published_or_final_version / Medical Sciences / Master / Master of Medical Sciences
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Elucidation of ganglioside binding domain in the B-subunit of cholera toxin檀東煇, Tan, T. F. January 2000 (has links)
published_or_final_version / Biochemistry / Master / Master of Philosophy
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Enzymatic studies on GM1 ganglioside biosynthesisRabinowitz-Kaplan, Fëıge. January 1981 (has links)
An enzyme that catalyzed the terminal step in GM(,1) ganglioside biosynthesis was demonstrated in rat brain and rat liver microsomal preparations. This galactosyltransferase enzyme could be solubilized from the Golgi fraction of rat liver homogenates. Anion exchange chromatography resolved two distinct enzymes with activity toward GM(,2) ganglioside. These two activities could be distinguished by such properties as pH optima, detergent requirements, and isoelectric points. The two enzymes had similar molecular weights and cation requirements. / Extensive characterization of the acceptor specificities of galactosyltransferase enzymes present in solubilized Golgi preparations led to the identification of five enzyme reactions. Two activities were identified which had a requirement for acceptors within the glycoprotein family. A single activity supported the biosynthesis of GM(,1) ganglioside only. The fourth galactosyltransferase activity catalyzed the incorporation of galactose into both ganglioside and glycoprotein.
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The role of mouse and human lysosomal sialidase in the catabolism of ganglioside GM2 /Gafuik, Chris. January 1999 (has links)
Tay-Sachs and Sandhoff diseases are autosomal recessive disorders of GM2 ganglioside catabolism resulting from deficient activity of lysosomal beta-hexosaminidase A (Hex A) or Hex A and Hex B, respectively. This leads to a massive and fatal accumulation of GM2 ganglioside in the neurons of affected patients. Mouse models of Tay-Sachs and Sandhoff diseases, created via targeted disruption of the Hexa and Hexb genes, revealed that while Hexb -/- mice suffer a profound, fatal neurodegenerative disease as expected, Hexa -/- mice escape disease to about one year. This protection is conferred by an ability to degrade GM2 ganglioside by means of a lysosomal sialidase mediated metabolic bypass. To determine if such a bypass could be made to function in humans, a series of experiments were performed to examine and compare the activity of mouse and human lysosomal sialidases in their ability to promote GM2 catabolism. The results suggest that human lysosomal sialidase, though sluggish, can indeed degrade GM2 when induced sufficiently.
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Biochemical genetic studies on ganglioside biosynthesis in miceSokoloff, Dina January 1987 (has links)
No description available.
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A resonant mirror biosensor approach to understand antibody-antigen interactions in Guillain-Barré syndromeVan der Merwe, Hermanus Daniël. January 2007 (has links)
Thesis (MSc Natural and Agricultural Sciences (Biochemistry))-University of Pretoria, 2007. / Summary in English and Afrikaans. Includes bibliographical references. Available on the Internet via the World Wide Web.
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The biological significance and role of GD3 ganglioside in U1242MG glioma cellsOmran, Ola Mahmoud Farghly, January 2004 (has links)
Thesis (Ph. D.)--Ohio State University, 2004. / Title from first page of PDF file. Document formatted into pages; contains xvi, 134 p. : ill. (some col.). Advisor: Allan J. Yates, Dept. of Pathology. Includes bibliographical references (p. 118-134).
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Physicochemical characterization of brain ganglioside-stimulated protein kinase /Wai, Sing-fai. January 1997 (has links)
Thesis (Ph. D.)--University of Hong Kong, 1997. / Includes bibliographical references (leaf 146).
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Elucidation of the sequence of the autophosphorylation site of ganglioside-stimulated protein kinaseWai, Chun-leung. January 2001 (has links)
Thesis (M.Med.Sc.)--University of Hong Kong, 2001. / Includes bibliographical references (leaves 64-72). Also available in print.
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