• Refine Query
  • Source
  • Publication year
  • to
  • Language
  • 86
  • 14
  • 10
  • 6
  • 6
  • 6
  • 6
  • 6
  • 6
  • 4
  • 4
  • 2
  • 2
  • 1
  • 1
  • Tagged with
  • 138
  • 138
  • 71
  • 33
  • 20
  • 20
  • 18
  • 17
  • 10
  • 9
  • 8
  • 8
  • 8
  • 7
  • 7
  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
91

Gene expression in the peripartum canine placenta

Fellows, Elizabeth Jane 30 August 2012 (has links)
This research investigated gene expression in the canine placenta during the peripartum period. Previous studies have recognized molecular changes that occur in the placenta around the time of placental release in other species, but no study has looked at gene expression in the late gestation canine placenta. Of particular significance for this thesis work is the groundwork laid for future studies modeling placental abnormalities in dogs (e.g. subinvolution of placental sites) and humans (e.g. preeclampsia, placenta accreta). Despite years of research in multiple species, the exact mechanisms and processes regulating trophoblast invasion and placental release remain unclear. Therefore, the specific objective of this research was to characterize gene expression changes that occur during the peripartum period in the dog using microarray and real-time RT-PCR. Following total RNA isolation, the microarray analysis was performed by hybridizing total RNA to the Canine 2.0 Array (Affymetrix, Santa Clara, CA). Microarray analysis was carried out using the limma and affy packages through the Bioconductor software in the R statistical environment. Differential expression was defined as p ��� 0.05, FDR p ��� 0.10 and a log fold change of ��� 1.2. Following cDNA synthesis, real-time RT-PCR was performed using TaqMan primer and probes that were pre-made and pre-optimized for canine tissues (Applied Biosystems, Carlsbad, CA). Microarray analysis showed differential expression in 18 genes between pre-term and pre-labor sample groups, 38 genes that were differentially expressed between pre-term and parturient samples and no genes that were differentially expressed between pre-labor and parturient samples. Microarray analysis led to the identification of several candidate genes for closer investigation using real-time RT-PCR. These genes included MMP-1, MMP-2, MMP-9, TIMP-2, VEGF-A, Flt-1, CD44, DAG-1, IL-6 and CXCL10. All of these genes have been linked to trophoblast invasion or regression or placental release in a number of species including humans, cattle and rodents. Using real-time RT-PCR, there was a significant difference in MMP-9 mRNA expression in pre-term samples compared to pre- labor and parturient samples (p<0.05). However, there was no significant difference in mRNA expression of MMP-2, TIMP-2, VEGF-A, Flt-1 CD44, DAG-1, IL-6 or CXCL10. Future studies may focus on additional candidate genes identified by microarray that play a role in tissue remodeling at the end of canine gestation such as IL-8, EPHX2, PI3 and SERPINE1. / Graduation date: 2013
92

Pre-operative anxiety and uncertainty in gynecological cancerpatients

Ismail, Zarina. January 2006 (has links)
published_or_final_version / Nursing Studies / Master / Master of Nursing in Advanced Practice
93

Living with cancer: husbands' view of life style changes

Graham, Vivian Earline January 1981 (has links)
No description available.
94

The effects of the selective estrogen receptor modulators MPP and raloxifene in normal and cancerous human and murine uterine tissue

Davis, Angela Marie. January 2007 (has links)
Thesis (M.S.)--University of Missouri-Columbia, 2007. / The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from title screen of research.pdf file (viewed on March 21, 2008) Includes bibliographical references.
95

Skeletal maturation of Danish school children in relation to height, sexual development, and social conditions

Andersen, Else, January 1968 (has links)
Thesis--Copenhagen. / Summary in Danish. Bibliography: p. [129]-131.
96

Skeletal maturation of Danish school children in relation to height, sexual development, and social conditions

Andersen, Else, January 1968 (has links)
Thesis--Copenhagen. / Summary in Danish. Bibliography: p. [129]-131.
97

Renin in the female genital tract

Eskildsen, Peter Claes. January 1975 (has links)
Thesis--Copenhagen University. / Summary in Danish. Includes index. Bibliography: p. 139-162.
98

Skeletal maturation of Danish school children in relation to height, sexual development, and social conditions.

Andersen, Else, January 1968 (has links)
Thesis--Copenhagen. / Summary in Danish. Bibliography: p. [129]-131.
99

'Courageous Negro servitors' and laboring Irish bodies an examination of antebellum-era modern American gynecology /

Cooper Owens, Deirdre Benia, January 1900 (has links)
Thesis (Ph. D.)--UCLA, 2008. / Vita. Includes bibliographical references (leaves 281-296).
100

Prevenção e diagnóstico de lesões HPV induzidas e carcinoma anal em mulheres atendidas na rede básica de saúde da cidade de Botucatu pelo método escovado do canal anal /

Lusoli, Rita de Cássia. January 2013 (has links)
Orientador: Rogério Saad Hossne / Coorientador: Sidney Roberto Nadal / Banca: Fábio Vieira Teixeira / Banca: Maria Aparecida C. Arruda Henry / Resumo: O Papiloma Vírus Humano (HPV), é considerado um problema mundial de saúde pública, sendo a doença sexualmente transmissível mais prevalente. Guarda uma relação direta com o risco e a incidência do câncer do canal anal. Seu diagnóstico, tratamento e seguimento são de extrema importância. Neste sentido o escovado do canal anal tem um papel fundamental no rastreamento e seguimento das lesões HPV induzidas e consequente evolução para o câncer anal. Determinar a ocorrência de lesão HPV induzida em mulheres que participam dos programas de prevenção do câncer de colo uterino nas Unidades Básicas de Saúde (UBS) no município de Botucatu. Trata-se de um estudo transversal observacional que teve 228 mulheres submetidas ao escovado do canal anal a fim de estabelecer a ocorrência de lesão HPV induzida e suas correlações com dados sociais e comportamentais. Os 11 casos que apresentaram alteração de ASCUS e LSIL no escovado do canal anal traziam relação com estado civil, baixa escolaridade, não prática do sexo seguro, e a prática do sexo anal / Abstract: Human Papillomavirus (HPV) has been a world concern in Public Health, and it is the most prevalent sexually transmitted disease. It has a direct association with the risk and incidence of cancer in the anal canal. Its diagnosis, treatment and follow-up are extremely important. Using this approach, the smear of the anal canal has a crucial role in the screening and follow up of HPV-induced lesions and in the resulting development of anal cancer. To determine the occurrence of HPVinduced lesions in women who attended programs of uterine cervix cancer prevention in Basic Health Units (BHU) in Botucatu city. It is a cross sectional observational study, in which 228 women underwent brushing of the anal canal in order to establish the occurrence of HPV-induced lesion and its correlation with social and behavioral data. The 11 cases which had ASCUS and LSIL changes in the smear of the anal canal were associated with marital status, low education level, practice of unsafe intercourse and anal intercourse / Mestre

Page generated in 0.0746 seconds