In the last decade Process Synthesis has been an emerging active area of research. Since 1999 at COMPS, we have continuously applied this technique to many studies and recently have carefully started to consider the integration of this technique with others to simplify multilevel process design. In this regard the need for new tools that do not require very accurate data or experimental technique has become an imperative for the initial analysis of systems. This thesis presents some of these results.Process synthesis requires new rapid tools for the assessment and comparison of new technologies (possibilities) in the process development stage.This thesis examines and formulates process synthesis problems in the case of separation processes (separation with mixing , separation with reaction).Using simple generic vectorial tools, the thesis addresses the folowing issue: How the topology and mapping of the process vector field defines patterns that may be used for alternative process synthesis solution and design (structure selection ,stability analysis or controllability etc...) . The tools presented are intended for preliminary process design and feasibility studies and will allow for simple comparisons of various options.The key principle used in the study is the exploitation of the generic vectorial representation of fundamental physical phenomena (separation, mixing , reaction) in the process models as used for process synthesis and analysis.The demonstrated power of this approach is that it allows one to exploit the formal mathematical similarities between the different processing modes. Extensive topological Reactive Column Profile has been generated and analysed, offering new insights for manipulation of process behaviour in process synthesis and design. The significance of the contribution of this research is in offering extended fundamental insigths in creating process synthesis options for reactive-separations systems, creating the essential structural basis for subsequent mathematical optimisation of the performanceof process designs.