The effects of globalization has created a new global consumer segment known as Cosmopolitanism. It is a globally substantial segment that captures “open-minded individuals whose consumption orientation transcends particular cultures, localities or communities and who appreciates diversity including trying products and services from a variety of countries”. In the same sense have global brands grown to take a central place on both developing and developed countries, and their competition with local brands has substantially increased. The Cosmopolitan consumer segment hold major strategic importance for global brands, but the understanding of this new segment has been markedly limited, especially on consumption related behavioral outcomes such as brand loyalty. Taking on a cross-national, comparative approach, the purpose of this study was; to understand the association between Cosmopolitanism and global brand loyalty in developing and developed countries.  Collecting data through online questionnaires in Sweden and Syria, 341 respondents were included within the study, and with regression analyses were three proposed hypotheses tested. The results showed a significant, but arguably weak, association between Cosmopolitanism and global brand loyalty. On the other hand, upon introducing economic development status as a moderating variable, it was seen that the association differed between the sampled countries, with a considerably stronger association in Syria. Managerial implications are presented based on these findings, and the paper is finalized with some essential limitations and avenues for suture research.