This study investigates the historical development and implementation of global governance theory, recognizing its collaborative framework as a critical tool in global politics. While the theory, alongside its epistemic foundations, offers productive and useful guidance for approaching transnational affairs, the question remains whether or not the application of this theory to reality has been successful and advantageous. In order to evaluate this translation, three key structures for transnational relations are examined: the Entente Cordiale, the League of Nations, and the European Union. By consulting key global governance theorists, academic assessments, as well as news reports, this paper analyzes and evaluates Europe’s use of a global governance framework. Although the reality of implementing this theory has exposed significant flaws, this study points to global governance theory as a valuable framework, suggesting the need to return to this theory, particularly for navigating through uncertainty and instability in global politics.